Glutathione—homocystine transhydrogenase
In enzymology, a glutathione—homocystine transhydrogenase (EC 1.8.4.1) is an enzyme that catalyzes the chemical reaction
- 2 glutathione + homocystine glutathione disulfide + 2 homocysteine
| glutathione—homocystine transhydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.8.4.1 | ||||||||
| CAS number | 9029-40-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are glutathione and homocystine, whereas its two products are glutathione disulfide and homocysteine.
This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with a disulfide as acceptor. The systematic name of this enzyme class is glutathione:homocystine oxidoreductase. This enzyme participates in methionine metabolism and glutathione metabolism.
References
- Racker E (December 1955). "Glutathione-homocystine transhydrogenase". The Journal of Biological Chemistry. 217 (2): 867–74. PMID 13271447.
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