Glutathione thiolesterase

In enzymology, a glutathione thiolesterase (EC 3.1.2.7) is an enzyme that catalyzes the chemical reaction

S-acylglutathione + H2O glutathione + a carboxylate
glutathione thiolesterase
Identifiers
EC number3.1.2.7
CAS number9025-99-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are S-acylglutathione and H2O, whereas its two products are glutathione and carboxylate.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is S-acylglutathione hydrolase. This enzyme is also called citryl-glutathione thioesterhydrolase.

References

    • KIELLEY WW, BRADLEY LB (1954). "Glutathione thiolesterase". J. Biol. Chem. 206 (1): 327–33. PMID 13130552.


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