HBG2

Hemoglobin subunit gamma-2 is a protein that in humans is encoded by the HBG2 gene.[5]

HBG2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FDH, 4MQJ, 4MQK
Identifiers
Aliases	HBG2, HBG-T1, TNCY, hemoglobin subunit gamma 2
External IDs	OMIM: 142250 MGI: 96027 HomoloGene: 128032 GeneCards: HBG2
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 5,253,188 bp[1] End 5,505,605 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 E3|7 54.85 cM Start 103,851,749 bp[2] End 103,853,216 bp[2]
Gene ontology Molecular function • iron ion binding • oxygen carrier activity • heme binding • metal ion binding • oxygen binding • peroxidase activity • GO:0001948 protein binding • haptoglobin binding • organic acid binding Cellular component • blood microparticle • hemoglobin complex • cytosol • haptoglobin-hemoglobin complex Biological process • oxygen transport • blood coagulation • transport • hydrogen peroxide catabolic process • protein heterooligomerization • cellular oxidant detoxification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3048	15135
Ensembl	ENSG00000196565	ENSMUSG00000052187
UniProt	P69892	P02104
RefSeq (mRNA)	NM_000184	NM_008221
RefSeq (protein)	NP_000175	NP_032247
Location (UCSC)	Chr 11: 5.25 – 5.51 Mb	Chr 7: 103.85 – 103.85 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The gamma globin genes (HBG1 and HBG2, this gene) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5' - epsilon – gamma-G – gamma-A – delta – beta - 3'.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000196565 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052187 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (May 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood. 73 (5): 1081–104. doi:10.1182/blood.V73.5.1081.1081. PMID 2649166.
6. "Entrez Gene: HBG2 hemoglobin, gamma G".

Further reading

• Gelinas R, Yagi M, Endlich B, et al. (1985). "Sequences of G gamma, A gamma, and beta genes of the Greek (A gamma) HPFH mutant: evidence for a distal CCAAT box mutation in the A gamma gene". Prog. Clin. Biol. Res. 191: 125–39. PMID 2413469.
• Anderson NL, Anderson NG (2003). "The human plasma proteome: history, character, and diagnostic prospects". Mol. Cell. Proteomics. 1 (11): 845–67. doi:10.1074/mcp.R200007-MCP200. PMID 12488461.

External links

• Overview of all the structural information available in the PDB for UniProt: P69892 (Hemoglobin subunit gamma-2) at the PDBe-KB.