Herbert Gutfreund

Herbert Gutfreund FRS is a British biochemist of Austrian origin, and Emeritus Professor at the University of Bristol.[1] He has been known almost universally as "Freddie" Gutfreund, but that is not part of his legal name.

Early life and education

Gutfreund was born on 21 October 1921 in Vienna to a middle-class professional family. His father was a civil engineer, and on his mother's side there were several scientists. He had all his early education in Vienna.[2] However, the political turmoil of the 1930s forced him to leave Austria for England after the Anschluss of 1938. He joined an agricultural training scheme and became an accomplished dairyman. His interest in physiology was stimulated by reading Principles of General Physiology.[3] by William Bayliss and he was much influenced by it. He earned his doctorate at Cambridge.

Career

Gutfreund spent most of his career at the University of Bristol, where he worked on proteolytic enzymes, including chymotrypsin and trypsin, and was especially active in using methods of studying fast reactions to study enzyme mechanisms. In this connection he developed and improved apparatus for that purpose.[4] He opposed the notion of metabolite channelling in glycolysis.[5]

Textbooks

Gutfreund is also known for his textbooks on various aspects of enzyme catalysis, including Enzymes: Physical Principles[6] and Kinetics for the Life Sciences: Receptors, Transmitters and Catalysts.[7] He collaborated with John Edsall on the book Biothermodynamics: The Study of Biochemical Processes at Equilibrium .[8]

Honours

He was elected to the Royal Society in 1981.[9]

References
  1. Bristol, University of. "Nobel Prizes and Fellowships - About the University - University of Bristol". Bris.ac.uk. Retrieved 1 November 2018.
  2. Gutfreund, Herbert (2007). "How I Became a Biochemist: An Honorary One!". IUBMB Life. 59 (11): 734–737. doi:10.1080/15216540701551775. PMID 17852567. S2CID 27847114.
  3. Bayliss, William Maddock (1918). Principles of general physiology. London: Longmans Green & Co.
  4. Gutfreund H (1999). "Rapid-flow techniques and their contributions to enzymology". Trends in Biochemical Sciences. 24: 458–460.
  5. Gutfreund H, Chock PB (1991). "Substrate channelling among glycolytic enzymes: fact or fiction". Journal of Theoretical Biology. 152 (1): 117–121. doi:10.1016/S0022-5193(05)80524-7. PMID 1753754.
  6. Gutfreund H (1972). Enzymes: Physical Principles. Wiley-Blackwell.
  7. Gutfreund H (1995). Kinetics for the Life Sciences: Receptors, Transmitters and Catalysts. Cambridge University Press.
  8. Edsall JT, Gutfreund H (1983). Biothermodynamics: The Study of Biochemical Processes at Equilibrium. Wiley-Blackwell.
  9. "Herbert Gutfreund". Royal Society. 1 September 2015. Retrieved 10 October 2018.
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