Hygromycin-B kinase
In enzymology, a hygromycin-B kinase (EC 2.7.1.119) is an enzyme that catalyzes the chemical reaction
- ATP + hygromycin B ADP + 7"-O-phosphohygromycin
| hygromycin B kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.7.1.119 | ||||||||
| CAS number | 88361-67-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are ATP and hygromycin B, whereas its two products are ADP and 7''-O-phosphohygromycin.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:hygromycin-B 7"-O-phosphotransferase. This enzyme is also called hygromycin B phosphotransferase.
References
- Zalacain M, Pardo JM, Jimenez A (1987). "Purification and characterization of a hygromycin B phosphotransferase from Streptomyces hygroscopicus". Eur. J. Biochem. 162 (2): 419–22. doi:10.1111/j.1432-1033.1987.tb10618.x. hdl:10261/57133. PMID 3026811.
- Pardo JM, Malpartida F, Rico M, Jimenez A (1985). "Biochemical basis of resistance to hygromycin B in Streptomyces hygroscopicus - the producing organism". J. Gen. Microbiol. 131 (6): 1289–1298. doi:10.1099/00221287-131-6-1289. PMID 2995542.
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