IFT81

Intraflagellar transport protein 81 homolog is a protein that in humans is encoded by the IFT81 gene.[5][6] Together with IFT74/72 it forms a core complex to build IFT particles[7] which are required for cilium formation. Additionally, it interacts with basal body components as CEP170[8] which regulates the disassembly of the cilium.

IFT81
Identifiers
Aliases	IFT81, CDV-1, CDV-1R, CDV1, CDV1R, DV1, intraflagellar transport 81, SRTD19
External IDs	OMIM: 605489 MGI: 1098597 HomoloGene: 7664 GeneCards: IFT81
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.11 Start 110,124,335 bp[1] End 110,218,793 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 F|5 62.44 cM Start 122,550,204 bp[2] End 122,614,518 bp[2]
Gene ontology Molecular function • tubulin binding • GO:0001948 protein binding Cellular component • intraciliary transport particle B • ciliary basal body • centrosome • sperm principal piece • cell projection • ciliary tip • motile cilium • sperm midpiece • cilium Biological process • cell projection organization • spermatogenesis • intraciliary transport • intraciliary transport involved in cilium assembly • cilium morphogenesis • regulation of smoothened signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	28981	12589
Ensembl	ENSG00000122970	ENSMUSG00000029469
UniProt	Q8WYA0	O35594
RefSeq (mRNA)	NM_001143779 NM_014055 NM_031473 NM_001347946 NM_001347947 NM_001347948	NM_009879 NM_001358917 NM_001358918 NM_001358919
RefSeq (protein)	NP_001137251 NP_054774 NP_113661 NP_001334875 NP_001334876 NP_001334877 NP_001137251.1 NP_054774.2	NP_034009 NP_001345846 NP_001345847 NP_001345848
Location (UCSC)	Chr 12: 110.12 – 110.22 Mb	Chr 5: 122.55 – 122.61 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000122970 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029469 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: intraflagellar transport 81 homolog (Chlamydomonas)".
6. Higashi M, Kobayashi K, Iijima M, Wakana S, Horiuchi M, Yasuda T, Yoshida G, Kanmura Y, Saheki T (December 2000). "Genomic organization and mapping of mouse CDV (carnitine deficiency-associated gene expressed in ventricle)-1 and its related CDV-1R gene". Mamm. Genome. 11 (12): 1053–7. doi:10.1007/s003350010207. PMID 11130971. S2CID 9319574.
7. Lucker BF, Behal RH, Qin H, Siron LC, Taggart WD, Rosenbaum JL, Cole DG (July 2005). "Characterization of the intraflagellar transport complex B core: direct interaction of the IFT81 and IFT74/72 subunits". J. Biol. Chem. 280 (30): 27688–96. doi:10.1074/jbc.M505062200. PMID 15955805.
8. Lamla, Stefan (2009). Functional characterisation of the centrosomal protein Cep170 (Thesis). LMU München: Faculty of Biology.

Further reading

• Melzer D, Perry JR, Hernandez D, et al. (2008). Cheung VG (ed.). "A genome-wide association study identifies protein quantitative trait loci (pQTLs)". PLOS Genet. 4 (5): e1000072. doi:10.1371/journal.pgen.1000072. PMC 2362067. PMID 18464913.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Peng J, Yu L, Horiuchi M, et al. (2002). "Identification of human CDV-1R and mouse Cdv-1R, two novel proteins with putative signal peptides, especially highly expressed in testis and increased with the male sex maturation". Mol. Biol. Rep. 29 (4): 353–62. doi:10.1023/A:1021232518628. PMID 12549821. S2CID 908688.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.