CEP170

Centrosomal protein 170kDa, also known as CEP170, is a protein that in humans is encoded by the CEP170 gene.[5][6]

CEP170
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4JON
Identifiers
Aliases	CEP170, FAM68A, KAB, KIAA0470, centrosomal protein 170
External IDs	OMIM: 613023 MGI: 1918348 HomoloGene: 22844 GeneCards: CEP170
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q43 Start 243,124,428 bp[1] End 243,255,348 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H4 Start 176,733,653 bp[2] End 176,814,067 bp[2]
Orthologs
Species	Human	Mouse
Entrez	9859	545389
Ensembl	ENSG00000143702 ENSG00000276725	ENSMUSG00000057335
UniProt	Q5SW79	Q6A065
RefSeq (mRNA)	NM_001042404 NM_001042405 NM_014812	NM_001024722 NM_001099637 NM_001368872 NM_001368873
RefSeq (protein)	NP_001035863 NP_001035864 NP_055627	NP_001093107 NP_001355801 NP_001355802
Location (UCSC)	Chr 1: 243.12 – 243.26 Mb	Chr 1: 176.73 – 176.81 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with the intraflagellar transport protein 81 (IFT81), the SH3-domain containing protein PRAX-1, and is phosphorylated by cyclin dependent kinase 1 (Cdk1) and polo-like kinase 1 (PLK1), and functions in maintaining Microtubule organization, cell morphology and cilium stability.[5]

The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined.[5]

References

1. ENSG00000276725 GRCh38: Ensembl release 89: ENSG00000143702, ENSG00000276725 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000057335 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CEP170 centrosomal protein 170kDa".
6. Guarguaglini G, Duncan PI, Stierhof YD, Holmström T, Duensing S, Nigg EA (March 2005). "The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles". Molecular Biology of the Cell. 16 (3): 1095–107. doi:10.1091/mbc.E04-10-0939. PMC 551476. PMID 15616186.

External links

• Human CEP170 genome location and CEP170 gene details page in the UCSC Genome Browser.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Centrosomal protein of 170 kDa (CEP170)

Further reading

• Andersen JS, Wilkinson CJ, Mayor T, et al. (2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Guarguaglini G, Duncan PI, Stierhof YD, et al. (2005). "The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles". Mol. Biol. Cell. 16 (3): 1095–107. doi:10.1091/mbc.E04-10-0939. PMC 551476. PMID 15616186.
• Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Lamla S (2009). "Functional characterisation of the centrosomal protein Cep170". Dissertation, LMU Muenchen: Fakultät für Biologie. URN nbn:de:bvb:19-97838.