Inferior olivary nucleus

The inferior olivary nucleus (ION), is a structure found in the medulla oblongata underneath the superior olivary nucleus.[1] In vertebrates, the ION is known to coordinate signals from the spinal cord to the cerebellum to regulate motor coordination and learning.[2] These connections have been shown to be tightly associated, as degeneration of either the cerebellum or the ION results in degeneration of the other.[3][4]

Inferior olivary nucleus
Microcircuitry of the cerebellum. Excitatory synapses are denoted by (+) and inhibitory synapses by (-).
MF: Mossy fiber.
DCN: Deep cerebellar nuclei.
IO: Inferior olive.
CF: Climbing fiber.
CFC: Climbing fiber collateral.
GC: Granule cell.
PF: Parallel fiber.
PC: Purkinje cell.
GgC: Golgi cell.
SC: Stellate cell.
BC: Basket cell.
Transverse section of medulla oblongata below the middle of the olive. (Inferior olivary nucleus labeled at center right.)
Details
Part ofOlivary body
Identifiers
LatinComplexus olivaris inferior,
nuclei olivares inferiores
NeuroNames748
TA98A14.1.04.008
A14.1.04.219
TA25988, 6021
FMA72243
Anatomical terms of neuroanatomy

Though neurons of the ION are glutamatergic, they receive inhibitory input via GABA receptors.[1] There are two distinct GABAα receptor populations that are spatially organized within each neuron present in the ION. The GABAα receptor make-up varies based on where the receptor localizes on the ION neuron.[5] The reason for this spatial distribution is unknown. It has been proposed that the distinct populations of GABAα receptors allows for fine-tuned regulation within the ION.[5]

Structure

The inferior olivary nucleus (ION) has a distinct laminar structure.[1] These lamina house the cell bodies of the olivocerebellar fibers. These neurons are the major input source for the cerebellum.[1] Their axons are referred to as climbing fibers. These climbing fibers leave the ION medially through the hilum, cross the midline, and ascend into the cerebellum via the inferior cerebellar peduncle.[1] The target for each climbing fiber is a specific neuron in the cerebellum referred to as a Purkinje Cell. During development, there are multiple climbing fibers on a purkinje cell, however these are pruned off during postnatal development, thus leaving a mature purkinje cell with a single climbing fiber.

There are three major components of the IO.[6]

  1. Primary olivary nucleus (PO) – This is the major laminar structure, and its distinct folds can be seen clearly.[6] 
  2. Medial accessory olivary nucleus (MAO) – This nucleus is between the PO and the pyramids. It is visualized as a curved lamina.[6]
  3. Dorsal accessory olivary nucleus (DAO) – This nucleus also is a curved lamina. It is the smallest nucleus in the IO and is behind the PO.[6] 

Function

Motor coordination and learning

Patient studies revealed the connection between the inferior olivary nucleus (ION) and the cerebellum. Lesions in the ION impair the ability to learn higher level motility, such as performing a perfect jumpshot.[7] Further investigation of the neuroanatomy confirmed the intimate connection between the IO and the cerebellum in motor coordination and learning.[2] 

The IO sends signals to the cerebellum based on information sent from the spino-olivary tract. Regulation following this point is highly debated. The original hypothesis as to how the IO influenced the cerebellum involved long term depression (LTD).[2] In this scenario, deep cerebellar nuclei send GABA projection to inhibit ION. More recent studies suggest that encoding the timing of sensory input is the key component of these connections.[8] The ION sends signals through different cell clusters. These signals vary in location and in frequency bundles and appear inconsistent. However, the temporal pattern of these signals is consistent.[8] Therefore, ongoing research on motor learning is investigating how these timed signals develop and their role in motor learning.

Steroidogenesis

The inferior olivary nucleus (ION) expresses key enzymes involved in steroidogenesis required for neuroprotection and maintenance.[9] The most crucial of these enzymes is aromatase, which is the enzyme that is necessary for the conversion of testosterone into estradiol.[10] Without aromatase, the ION is unable to make estradiol, and cannot recover from injury properly.[9]

Clinical significance

Because the inferior olivary nucleus (ION) is tightly associated with the cerebellum, lesions in either the IO or the cerebellum results in degeneration in the other. There is little known about damage to the inferior olivary nucleus (IO) independent from the cerebellum. To date, the only known disorder which specifically targets the ION is an extremely rare form of degeneration called hypertrophic olivary degeneration (HOD).[11]

Although the ION is not often investigated on its own, degeneration in the ION has been identified in disorders that are typically associated with the cerebellum. These disorders include supranuclear palsy,[12] Leigh disease,[13] and SCA6,[14] and there are several more. These disorders all involve motor coordination.[12][13][14]

Additional images
  • Sagittal section through right cerebellar hemisphere. The right olive has also been cut sagittally.

References

This article incorporates text in the public domain from page 781 of the 20th edition of Gray's Anatomy (1918)

  1. Gado, Thomas A. Woolsey; Joseph Hanaway; Mokhtar H. (2003). The brain atlas a visual guide to the human central nervous system (2nd ed.). Hoboken, NJ: Wiley. p. 206. ISBN 0-471-43058-7.
  2. Schweighofer N, Lang EJ, Kawato M. Role of the olivo-cerebellar complex in motor learning and control. Frontiers in Neural Circuits. 2013;7:94. doi:10.3389/fncir.2013.00094.
  3. Brodal A., Kawamura K. (1980). The Inferior Olive. Notes on its Comparative Anatomy, Morphology, and Cytology. In: Olivocerebellar Projection. Advances in Anatomy Embryology and Cell Biology, vol 6. Berlin, Heidelberg: Springer. ISBN 978-3-642-67775-5.
  4. Gatlin JL, Wineman R, Schlakman B, Buciuc R, Khan M. Hypertrophic Olivary Degeneration After Resection of a Pontine Cavernous Malformation: A Case Report. Journal of Radiology Case Reports. 2011;5(3):24-29. doi:10.3941/jrcr.v5i3.603.
  5. Alastair M. Hosie, Megan E. Wilkins, Helena M. A. da Silva & Trevor G. Smart. Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites. Nature 444, 486-489. doi:10.1038/nature05324
  6. Ausim Azizi, S. (2007-10-02). ". . . And the Olive Said to the Cerebellum: Organization and Functional Significance of the Olivo-Cerebellar System". The Neuroscientist. 13 (6): 616–625. doi:10.1177/1073858407299286. PMID 17911222.
  7. Martin TA, Keating JG, Goodkin HP, Bastian AJ, Thach WT. Throwing while looking through prisms. I. Focal olivocerebellar lesions impair adaptation. Brain 1996; 119: 1183-1198.
  8. Liu T, Xu D, Ashe J, Bushara K. Specificity of inferior olive response to stimulus timing. J Neurophysiol 2008; 100: 1557-61.
  9. Sierra A1, Azcoitia I, Garcia-Segura L. Endogenous estrogen formation is neuroprotective in model of cerebellar ataxia. Endocrine. 2003 Jun;21(1):43-51.
  10. Biegon A. In vivo visualization of aromatase in animals and humans. Frontiers in Neuroendocrinology. 2016;40:42-51. doi:10.1016/j.yfrne.2015.10.001.
  11. Elnekiedy, Abdelaziz; Naguib, Nagy; Hamed, Waseem; Mekky, Jaidaa; Hassan, Hebatallah Hassan Mamdouh (2016). "MRI and neurological presentation of hypertrophic olivary degeneration". The Egyptian Journal of Radiology and Nuclear Medicine. 47 (3): 1019–1029. doi:10.1016/j.ejrnm.2016.04.019.
  12. Hanihara, T.; Amano, N.; Takahashi, T.; Itoh, Y.; Yagishita, S. (1998). "Hypertrophy of the inferior olivary nucleus in patients with progressive supranuclear palsy". European Neurology. 39 (2): 97–102. doi:10.1159/000007915. ISSN 0014-3022. PMID 9520070.
  13. Bindu, P S; Taly, A B; Sonam, K; Govindaraju, C; Arvinda, H R; Gayathri, N; Bharath, M M Srinivas; Ranjith, D; Nagappa, M (2014-01-24). "Bilateral hypertrophic olivary nucleus degeneration on magnetic resonance imaging in children with Leigh and Leigh-like syndrome". The British Journal of Radiology. 87 (1034): 20130478. doi:10.1259/bjr.20130478. ISSN 0007-1285. PMC 4064547. PMID 24470583.
  14. Koeppen, Arnulf H. (2005-03-01). "The pathogenesis of spinocerebellar ataxia". The Cerebellum. 4 (1): 62–73. doi:10.1080/14734220510007950. ISSN 1473-4222. PMID 15895563.
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