L-dopachrome isomerase
In enzymology, a L-dopachrome isomerase (EC 5.3.3.12) is an enzyme that catalyzes the chemical reaction
- L-dopachrome 5,6-dihydroxyindole-2-carboxylate
| dopachrome isomerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 5.3.3.12 | ||||||||
| CAS number | 130122-81-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Hence, this enzyme has one substrate, L-dopachrome, and one product, 5,6-dihydroxyindole-2-carboxylate.
This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is L-dopachrome keto-enol isomerase. Other names in common use include dopachrome tautomerase, tyrosinase-related protein 2, TRP-1, TRP2, TRP-2, tyrosinase-related protein-2, dopachrome Delta7,Delta2-isomerase, dopachrome Delta-isomerase, dopachrome conversion factor, dopachrome isomerase, dopachrome oxidoreductase, dopachrome-rearranging enzyme, DCF, DCT, dopachrome keto-enol isomerase, and L-dopachrome-methyl ester tautomerase. This enzyme participates in tyrosine metabolism and melanogenesis.
References
- Jara JR, Lozano JA (January 15, 1996). "Molecular mechanism for catalysis by a new zinc-enzyme, dopachrome tautomerase". Biochem. J. 313 (2): 447–53. PMC 1216928. PMID 8573077.
- Pawelek JM (1990). "Dopachrome conversion factor functions as an isomerase". Biochem. Biophys. Res. Commun. 166 (3): 1328–33. doi:10.1016/0006-291X(90)91011-G. PMID 2106316.
- Joshua GW, Selkirk ME, Zhang Y, Meyer DJ (November 1, 1998). "Rapid purification and characterization of L-dopachrome-methyl ester tautomerase (macrophage-migration-inhibitory factor) from Trichinella spiralis, Trichuris muris and Brugia pahangi". Biochem. J. 335 (3): 495–8. PMC 1219807. PMID 9794786.