LCOR

Ligand-dependent corepressor is a protein that in humans is encoded by the LCOR gene.[3][4][5]

LCOR
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2COB
Identifiers
Aliases	LCOR, MLR2, ligand dependent nuclear receptor corepressor, C10orf12
External IDs	OMIM: 607698 HomoloGene: 22914 GeneCards: LCOR
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.1 Start 96,832,282 bp[1] End 96,995,959 bp[1]
Gene ontology Molecular function • DNA binding • GO:0001948 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • transcription factor binding Cellular component • cell nucleus • nucleoplasm Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84458	n/a
Ensembl	ENSG00000196233	n/a
UniProt	Q96JN0	n/a
RefSeq (mRNA)	NM_001170765 NM_001170766 NM_001346516 NM_015652 NM_032440	n/a
RefSeq (protein)	NP_001164236 NP_001164237 NP_001333445 NP_115816	n/a
Location (UCSC)	Chr 10: 96.83 – 97 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Function

LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000196233 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Fernandes I, Bastien Y, Wai T, Nygard K, Lin R, Cormier O, Lee HS, Eng F, Bertos NR, Pelletier N, Mader S, Han VK, Yang XJ, White JH (Jan 2003). "Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms". Mol Cell. 11 (1): 139–50. doi:10.1016/S1097-2765(03)00014-5. PMID 12535528.
4. White JH, Fernandes I, Mader S, Yang XJ (Jun 2004). "Corepressor recruitment by agonist-bound nuclear receptors". Vitam Horm. Vitamins & Hormones. 68: 123–43. doi:10.1016/S0083-6729(04)68004-6. ISBN 9780127098685. PMID 15193453.
5. "Entrez Gene: LCOR ligand dependent nuclear receptor corepressor".

Further reading

• Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kunieda T, Park JM, Takeuchi H, Kubo T (2003). "Identification and characterization of Mlr1,2: two mouse homologues of Mblk-1, a transcription factor from the honeybee brain(1)". FEBS Lett. 535 (1–3): 61–5. doi:10.1016/S0014-5793(02)03858-9. PMID 12560079. S2CID 83745027.
• Shi Y, Sawada J, Sui G, et al. (2003). "Coordinated histone modifications mediated by a CtBP co-repressor complex". Nature. 422 (6933): 735–8. doi:10.1038/nature01550. PMID 12700765. S2CID 2670859.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Ligand-dependent corepressor