Lesley Stewart

Lesley Ann Stewart (born 27 May 1963) is a Scottish academic whose research interests are in the development and application of evidence synthesis methods, particularly systematic reviews and individual participant data meta-analysis. She was one of the founders of the Cochrane Collaboration in 1993. Stewart served as President of the Society for Research Synthesis Methodology (2013-2016) and is the Co-editor in chief of the academic journal Systematic Reviews.

Lesley Stewart
Born27 May 1963
Dundee, Scotland
NationalityScottish
Alma materUniversity of Glasgow (BSc)
University of York (MSc)
University of East Anglia (PhD)
OccupationResearcher, professor
Known forResearch on systematic reviews and meta-analyses

Education

Stewart attended a state comprehensive school, leaving in 1980 to attend University. She graduated with a BSc in Zoology from the University of Glasgow in 1984, an MSc in Biological Computation (mathematics, statistics and computing relating to biological science) from the University of York in 1985 and a PhD in ecology from the University of East Anglia in 1988.

Career

Stewart joined the Medical Research Council (MRC) Cancer Trials Office in Cambridge in 1988 to carry out an "overview" synthesizing individual participant data from randomized trials of chemotherapy in advanced ovarian cancer. She was therefore fortunate enough to be part of the early development of systematic review methods. In particular, with colleagues including Mike Clarke and later Jayne Tierney, she helped establish the methods and practical approaches of systematic reviews and meta-analyses of individual participant data (IPD). Stewart and Clarke were amongst the founding members of the Cochrane Collaboration and in 1993 Stewart, Clarke and Tierney established the Cochrane IPD meta-analysis methods group.[1]

Stewart worked for the MRC for 17 years establishing a research programme in the Cancer Trials Office in Cambridge and subsequently (following a merger of two groups) in the MRC Clinical Trials Unit under the Directorship of Professor Janet Darbyshire. During this time with her research team she published many systematic reviews and IPD meta-analyses.[2]

In 2006 she was appointed as professor and Director of the Centre for Reviews and Dissemination at the University of York,[3] where alongside her role as Director she has maintained her research interests in systematic review methods and IPD.[4][5][6][7][8]

Stewart has long standing interest in transparency and data sharing. For example, she has contributed to reporting standards for protocols and IPD meta-analysis.[4][9] Whilst at the MRC she was responsible for launching the first completely open web based register of clinical trials, the UKCCCR of cancer trials.[10] At CRD she instigated the development of PROSPERO the open access international prospective register of systematic reviews.[11][12][13][14][15][16] She was able to bring these research strands together and be part of the YODA initiative’s[17][18] first project to provide independent re-analysis and synthesis of industry data.

Stewart is Co-editor in chief of the BioMed Central (BMC) journal Systematic Reviews. She currently serves on the National Institute for Health and Care Excellence (NICE) Highly Specialised Technologies Committee.

Stewart was one of the first cohort of National Institute for Health Research (NIHR) Senior Investigators (2008 – 2013). In 2013, she was elected to serve as president of the Society for Research Synthesis Methodology.[19]

Personal

Stewart lives in York with her husband Simon Thornton and their two daughters.

References
  1. "Welcome to the IPD Meta-analysis Methods Group". Cochrane Individual Participant Data (IPD) Meta-analysis Methods Group. The Cochrane Collaboration. 6 January 2015. Retrieved 23 May 2015.
  2. Stewart, LA; Parmar, MKB (1993). "Meta-analysis of the literature or of individual patient data: is there a difference?". Lancet. 341 (8842): 418–422. doi:10.1016/0140-6736(93)93004-K. PMID 8094183. S2CID 34704861.
  3. "Centre for Reviews and Dissemination". The University of York Centre for Reviews and Dissemination. University of York. 2015. Retrieved 23 May 2015.
  4. Stewart, LA; Clarke, M; Rovers, M; Riley, RD; Simmonds, M; Stewart, G; Tierney, JF; PRISMA-IPD, Development Group (2015). "Preferred Reporting Items for Systematic Review and Meta-Analyses of individual participant data: the PRISMA-IPD Statement". JAMA. 313 (16): 1657–1665. doi:10.1001/jama.2015.3656. PMID 25919529.
  5. Stewart, GB; Altman, DG; Askie, LM; Duley, L; Simmonds, MC; Stewart, LA (2012). "Statistical analysis of individual participant data meta-analyses: a comparison of methods and recommendations for practice". PLOS ONE. 7 (10): e46042. Bibcode:2012PLoSO...746042S. doi:10.1371/journal.pone.0046042. PMC 3463584. PMID 23056232.
  6. Simmonds, MC; Higgins, JP; Stewart, LA; Tierney, JF; Clarke, MJ; Thompson, SG (2005). "Meta-analysis of individual patient data from randomized trials: a review of methods used in practice". Clin Trials. 2 (3): 209–217. doi:10.1191/1740774505cn087oa. PMID 16279144. S2CID 24916211.
  7. Tierney, JF; Stewart, LA (2005). "Investigating patient exclusion bias in meta-analysis". Int J Epidemiol. 34 (1): 79–87. doi:10.1093/ije/dyh300. PMID 15561753. Retrieved 25 May 2015.
  8. Stewart, LA; Tierney, JF (2002). "To IPD or not to IPD? Advantages and disadvantages of systematic reviews using individual patient data". Eval Health Prof. 25 (1): 76–97. doi:10.1177/0163278702025001006. PMID 11868447. S2CID 1323552.
  9. Moher, D; Shamseer, L; Clarke, M; Ghersi, D; Liberati, A; Petticrew, M; Shekelle, P; Stewart, LA; PRISMA-P, Group (2015). "Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement". Syst Rev. 4 (1): 1. doi:10.1186/2046-4053-4-1. PMC 4320440. PMID 25554246.
  10. Vale, C; Stewart, L; Tierney, J (2005). "Trends in UK Cancer Trials: Results from the UK Coordinating Committee for Cancer Research National Register of Cancer Trials". Br J Cancer. 92 (5): 811–814. doi:10.1038/sj.bjc.6602425. PMC 2361907. PMID 15756251.
  11. "PROSPERO - International prospective register of systematic reviews". The University of York Centre for Reviews and Dissemination. University of York. 29 April 2015. Retrieved 23 May 2015.
  12. Booth, A; Stewart, L (2013). "Trusting researchers to use open trial registers such as PROSPERO responsibly". BMJ. 347 (f5870): f5870. doi:10.1136/bmj.f5870. PMID 24088555. S2CID 206900112. Retrieved 25 May 2015.
  13. Stewart, L; Moher, D; Shekelle, P (2012). "Why prospective registration of systematic reviews makes sense". Syst Rev. 1 (7): 7. doi:10.1186/2046-4053-1-7. PMC 3369816. PMID 22588008.
  14. Booth, A; Clarke, M; Dooley, G; Ghersi, D; Moher, D; Petticrew, M; Stewart, L (2012). "The nuts and bolts of PROSPERO: an international prospective register of systematic reviews". Syst Rev. 1 (2): 2. doi:10.1186/2046-4053-1-2. PMC 3348673. PMID 22587842.
  15. Booth, A; Clarke, M; Ghersi, D; Moher, D; Petticrew, M; Stewart, L (2011). "Establishing a minimum dataset for prospective registration of systematic reviews: an international consultation". PLOS ONE. 6 (11): e27319. Bibcode:2011PLoSO...627319B. doi:10.1371/journal.pone.0027319. PMC 3217945. PMID 22110625. Retrieved 25 May 2015.
  16. Booth, A; Clarke, M; Ghersi, D; Moher, D; Petticrew, M; Stewart, L (2011). "An international registry of systematic-review protocols" (PDF). Lancet. 377 (9760): 108–109. doi:10.1016/S0140-6736(10)60903-8. PMID 20630580. S2CID 30588870. Retrieved 25 May 2015.
  17. "YODA Project". Center for Outcomes Research & Evaluation (CORE). Yale School of Medicine. 2015. Retrieved 23 May 2015.
  18. Rodgers, MA; Brown, JV; Heirs, MK; Higgins, JP; Mannion, RJ; Simmonds, MC; Stewart, LA (2013). "Reporting of industry funded study outcome data: comparison of confidential and published data on the safety and effectiveness of rhBMP-2 for spinal fusion". BMJ. 346 (f3981): f3981. doi:10.1136/bmj.f3981. PMC 3687771. PMID 23788229. Retrieved 25 May 2015.
  19. "Society for Research Synthesis Methodology - Home". Society for Research Synthesis Methodology. Society for Research Synthesis Methodology. 2015. Retrieved 23 May 2015.
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