Luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase
In enzymology, a luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase (EC 2.4.1.191) is an enzyme that catalyzes the chemical reaction
- UDP-glucuronate + luteolin 7-O-beta-D-diglucuronide UDP + luteolin 7-O-[beta-D-glucuronosyl-(1->2)-beta-D-glucuronide]-4'-O-beta-D- glucuronide
| luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.1.191 | ||||||||
| CAS number | 115490-50-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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Thus, the two substrates of this enzyme are UDP-glucuronate and luteolin 7-O-beta-D-diglucuronide, whereas its 4 products are UDP, luteolin, [[7-O-[beta-D-glucuronosyl-(1->2)-beta-D-glucuronide]-4'-O-beta-D-]], and glucuronide.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-glucuronate:luteolin-7-O-beta-D-diglucuronide 4'-O-glucuronosyltransferase. Other names in common use include uridine diphosphoglucuronate-luteolin 7-O-diglucuronide, glucuronosyltransferase, UDP-glucuronate:luteolin 7-O-diglucuronide-glucuronosyltransferase, UDPglucuronate:luteolin, 7-O-diglucuronide-4'-O-glucuronosyl-transferase, and LDT.
References
- Schulz M, Weissenbock G (1988). "3 specific UDP-glucuronate-flavone-glucuronosyl-transferases from primary leaves of Secale cereale". Phytochemistry. 27 (5): 1261–1267. doi:10.1016/0031-9422(88)80175-4.