MAL2 (gene)

Protein MAL2 is a protein that in humans is encoded by the MAL2 gene.[5][6]

MAL2
Identifiers
Aliases	MAL2, mal, T-cell differentiation protein 2 (gene/pseudogene), mal, T cell differentiation protein 2 (gene/pseudogene), mal, T cell differentiation protein 2
External IDs	OMIM: 609684 MGI: 2146021 HomoloGene: 14167 GeneCards: MAL2
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.12 Start 119,165,034 bp[1] End 119,245,673 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 D1 Start 54,571,192 bp[2] End 54,602,847 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • structural constituent of myelin sheath Cellular component • cytoplasm • perinuclear region of cytoplasm • cell membrane • extracellular exosome • apical plasma membrane • membrane • endomembrane system • membrane raft • integral component of membrane • integral component of synaptic vesicle membrane • hippocampal mossy fiber to CA3 synapse • glutamatergic synapse Biological process • transcytosis • membrane raft polarization • protein localization • myelination Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	114569	105853
Ensembl	ENSG00000147676	ENSMUSG00000024479
UniProt	Q969L2	Q8BI08
RefSeq (mRNA)	NM_052886	NM_178920
RefSeq (protein)	NP_443118 NP_443118.1	NP_849251
Location (UCSC)	Chr 8: 119.17 – 119.25 Mb	Chr 15: 54.57 – 54.6 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface.[6]

Interactions

MAL2 (gene) has been shown to interact with TPD52.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000147676 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024479 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wilson SH, Bailey AM, Nourse CR, Mattei MG, Byrne JA (Sep 2001). "Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system". Genomics. 76 (1–3): 81–8. doi:10.1006/geno.2001.6610. PMID 11549320.
6. "Entrez Gene: MAL2 mal, T-cell differentiation protein 2".

Further reading

• Marazuela M, Alonso MA (2004). "Expression of MAL and MAL2, two elements of the protein machinery for raft-mediated transport, in normal and neoplastic human tissue". Histol. Histopathol. 19 (3): 925–33. PMID 15168355.
• Rohan S, Tu JJ, Kao J, et al. (2007). "Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes". Clin. Cancer Res. 12 (23): 6937–45. doi:10.1158/1078-0432.CCR-06-1268. PMID 17145811.
• Barbaric D, Byth K, Dalla-Pozza L, Byrne JA (2007). "Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: clinical and sample considerations". Leuk. Res. 30 (11): 1355–63. doi:10.1016/j.leukres.2006.03.009. PMID 16620967.
• de Marco MC, Puertollano R, Martínez-Menárguez JA, Alonso MA (2006). "Dynamics of MAL2 during glycosylphosphatidylinositol-anchored protein transcytotic transport to the apical surface of hepatoma HepG2 cells". Traffic. 7 (1): 61–73. doi:10.1111/j.1600-0854.2005.00361.x. PMID 16445687. S2CID 44752098.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Llorente A, de Marco MC, Alonso MA (2005). "Caveolin-1 and MAL are located on prostasomes secreted by the prostate cancer PC-3 cell line". J. Cell Sci. 117 (Pt 22): 5343–51. doi:10.1242/jcs.01420. PMID 15466889.
• Marazuela M, Acevedo A, García-López MA, et al. (2004). "Expression of MAL2, an integral protein component of the machinery for basolateral-to-apical transcytosis, in human epithelia". J. Histochem. Cytochem. 52 (2): 243–52. doi:10.1177/002215540405200212. PMID 14729876.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Marazuela M, Martín-Belmonte F, García-López MA, et al. (2004). "Expression and distribution of MAL2, an essential element of the machinery for basolateral-to-apical transcytosis, in human thyroid epithelial cells". Endocrinology. 145 (2): 1011–6. doi:10.1210/en.2003-0652. PMID 14576188.
• Boutros R, Bailey AM, Wilson SH, Byrne JA (2003). "Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins". J. Mol. Biol. 332 (3): 675–87. doi:10.1016/S0022-2836(03)00944-6. PMID 12963375.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• de Marco MC, Martín-Belmonte F, Kremer L, et al. (2002). "MAL2, a novel raft protein of the MAL family, is an essential component of the machinery for transcytosis in hepatoma HepG2 cells". J. Cell Biol. 159 (1): 37–44. doi:10.1083/jcb.200206033. PMC 2173496. PMID 12370246.