TPD52

Tumor protein D52 is a protein that in humans is encoded by the TPD52 gene.[5][6]

TPD52
Identifiers
Aliases	TPD52, D52, N8L, PC-1, PrLZ, hD52, tumor protein D52
External IDs	OMIM: 604068 MGI: 107749 HomoloGene: 38007 GeneCards: TPD52
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q21.13 Start 80,034,745 bp[1] End 80,231,232 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 A1 Start 8,925,593 bp[2] End 9,004,723 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • GO:0001948 protein binding • protein homodimerization activity • protein heterodimerization activity Cellular component • cytoplasm • perinuclear region of cytoplasm • endoplasmic reticulum Biological process • B cell differentiation • anatomical structure morphogenesis • secretion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7163	21985
Ensembl	ENSG00000076554	ENSMUSG00000027506
UniProt	P55327	Q62393
RefSeq (mRNA)	NM_001025252 NM_001025253 NM_001287140 NM_001287142 NM_001287143 NM_001287144 NM_005079	NM_001025261 NM_001025262 NM_001025263 NM_001025264 NM_009412 NM_001357072 NM_001357073 NM_001357074
RefSeq (protein)	NP_001020423 NP_001020424 NP_001274069 NP_001274071 NP_001274072 NP_001274073 NP_005070	NP_001020432 NP_001020433 NP_001020434 NP_001020435 NP_033438 NP_001344001 NP_001344002 NP_001344003
Location (UCSC)	Chr 8: 80.03 – 80.23 Mb	Chr 3: 8.93 – 9 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TPD52 has been shown to interact with TPD52L2,[7] TPD52L1[7] and MAL2.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000076554 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027506 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Byrne JA, Tomasetto C, Garnier JM, Rouyer N, Mattei MG, Bellocq JP, Rio MC, Basset P (August 1995). "A screening method to identify genes commonly overexpressed in carcinomas and the identification of a novel complementary DNA sequence". Cancer Res. 55 (13): 2896–903. PMID 7796418.
6. "Entrez Gene: TPD52 tumor protein D52".
7. Byrne JA, Nourse CR, Basset P, Gunning P (February 1998). "Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system". Oncogene. 16 (7): 873–81. doi:10.1038/sj.onc.1201604. PMID 9484778.
8. Wilson SH, Bailey AM, Nourse CR, Mattei MG, Byrne JA (August 2001). "Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system". Genomics. 76 (1–3): 81–8. doi:10.1006/geno.2001.6610. PMID 11549320.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Chen SL, Maroulakou IG, Green JE, Romano-Spica V, Modi W, Lautenberger J, Bhat NK (1996). "Isolation and characterization of a novel gene expressed in multiple cancers". Oncogene. 12 (4): 741–51. PMID 8632896.
• Byrne JA, Mattei MG, Basset P (1996). "Definition of the tumor protein D52 (TPD52) gene family through cloning of D52 homologues in human (hD53) and mouse (mD52)". Genomics. 35 (3): 523–32. doi:10.1006/geno.1996.0393. PMID 8812487.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Byrne JA, Nourse CR, Basset P, Gunning P (1998). "Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system". Oncogene. 16 (7): 873–81. doi:10.1038/sj.onc.1201604. PMID 9484778.
• Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
• Wilson SH, Bailey AM, Nourse CR, Mattei MG, Byrne JA (2001). "Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system". Genomics. 76 (1–3): 81–8. doi:10.1006/geno.2001.6610. PMID 11549320.
• Sathasivam P, Bailey AM, Crossley M, Byrne JA (2001). "The role of the coiled-coil motif in interactions mediated by TPD52". Biochem. Biophys. Res. Commun. 288 (1): 56–61. doi:10.1006/bbrc.2001.5721. PMID 11594751.
• Boutros R, Bailey AM, Wilson SH, Byrne JA (2003). "Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins". J. Mol. Biol. 332 (3): 675–87. doi:10.1016/S0022-2836(03)00944-6. PMID 12963375.
• Wang R, Xu J, Saramäki O, Visakorpi T, Sutherland WM, Zhou J, Sen B, Lim SD, Mabjeesh N, Amin M, Dong JT, Petros JA, Nelson PS, Marshall FF, Zhau HE, Chung LW (2004). "PrLZ, a novel prostate-specific and androgen-responsive gene of the TPD52 family, amplified in chromosome 8q21.1 and overexpressed in human prostate cancer". Cancer Res. 64 (5): 1589–94. doi:10.1158/0008-5472.CAN-03-3331. PMID 14996714.
• Tiacci E, Orvietani PL, Bigerna B, Pucciarini A, Corthals GL, Pettirossi V, Martelli MP, Liso A, Benedetti R, Pacini R, Bolli N, Pileri S, Pulford K, Gambacorta M, Carbone A, Pasquarello C, Scherl A, Robertson H, Sciurpi MT, Alunni-Bistocchi G, Binaglia L, Byrne JA, Falini B (2005). "Tumor protein D52 (TPD52): a novel B-cell/plasma-cell molecule with unique expression pattern and Ca(2+)-dependent association with annexin VI". Blood. 105 (7): 2812–20. doi:10.1182/blood-2004-07-2630. PMID 15576473.
• Byrne JA, Balleine RL, Schoenberg Fejzo M, Mercieca J, Chiew YE, Livnat Y, St Heaps L, Peters GB, Byth K, Karlan BY, Slamon DJ, Harnett P, Defazio A (2005). "Tumor protein D52 (TPD52) is overexpressed and a gene amplification target in ovarian cancer". Int. J. Cancer. 117 (6): 1049–54. doi:10.1002/ijc.21250. PMID 15986428. S2CID 38845575.
• Boutros R, Byrne JA (2005). "D53 (TPD52L1) is a cell cycle-regulated protein maximally expressed at the G2-M transition in breast cancer cells". Exp. Cell Res. 310 (1): 152–65. doi:10.1016/j.yexcr.2005.07.009. PMID 16112108.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Barbaric D, Byth K, Dalla-Pozza L, Byrne JA (2007). "Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: clinical and sample considerations". Leuk. Res. 30 (11): 1355–63. doi:10.1016/j.leukres.2006.03.009. PMID 16620967.
• Cao Q, Chen J, Zhu L, Liu Y, Zhou Z, Sha J, Wang S, Li J (2006). "A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins". Biochem. Biophys. Res. Commun. 344 (3): 798–806. doi:10.1016/j.bbrc.2006.03.208. PMID 16631610.