Mark Achtman

Mark Achtman FRS[1] is Professor of Bacterial Population Genetics at Warwick Medical School, part of the University of Warwick in the UK.[2][3][4][5]

Mark Achtman
Mark Achtman in 2015, portrait via the Royal Society
Alma mater
Awards
Scientific career
Fields
Institutions
ThesisA Genetic Study of the F-Factor (1969)
Websitewww2.warwick.ac.uk/fac/med/staff/machtman

Education

Achtman was educated at the University of Manitoba where he was awarded a Master of Science degree in 1965 for research on hemagglutination in adenovirus.[6] He went on to complete a PhD on bacterial fertility factor at the University of California, Berkeley in 1969.[7][8]

Research

Achtman's research interests are in the population genetics of pathogenic bacteria such as Vibrio cholerae,[9] Salmonella,[10][11] Yersinia pestis,[12][13] Neisseria meningitidis,[14] Escherichia coli,[8] Helicobacter pylori,[15] and Bordetella.[16] Achtman was one of the inventors of multilocus sequence typing.[17] His research has been funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and Medical Research Council (MRC).[18]

Awards and honours

Achtman was elected a Fellow of the Royal Society (FRS) in 2015. His nomination reads:[1]

Mark Achtman co-pioneered the development of bacterial population genetics and carried out influential studies characterising strains associated with epidemics of meningococcal disease in Africa. He has undertaken remarkable and highly innovative studies on the human gut pathogen, Helicobacter pylori, showing its ancient association with humans and the ability of genetic studies of this pathogen to complement linguistic and human genetic studies to trace the ancient migrations of its human host. He has also carried out elegant and incisive genetic studies of Yersinia pestis to explore the origins and spread of plague pandemics.

References
  1. "Professor Mark Achtman FRS". London: The Royal Society. Archived from the original on 2 May 2015.
  2. Mark Achtman publications indexed by Google Scholar
  3. Mark Achtman's publications indexed by the Scopus bibliographic database. (subscription required)
  4. Kay, G. L.; Sergeant, M. J.; Zhou, Z; Chan, J. Z.; Millard, A; Quick, J; Szikossy, I; Pap, I; Spigelman, M; Loman, N. J.; Achtman, M; Donoghue, H. D.; Pallen, M. J. (2015). "Eighteenth-century genomes show that mixed infections were common at time of peak tuberculosis in Europe". Nature Communications. 6: 6717. doi:10.1038/ncomms7717. PMC 4396363. PMID 25848958.
  5. Achtman, M; Zhou, Z (2014). "Distinct genealogies for plasmids and chromosome". PLOS Genetics. 10 (12): e1004874. doi:10.1371/journal.pgen.1004874. PMC 4270482. PMID 25521852.
  6. Achtman, Mark (1965). Adenovirus 7: a study of the haemagglutinin and the haemagglutinating system (PhD thesis). University of Manitoba. OCLC 184853811.
  7. Achtman, Mark (1969). A Genetic Study of the F-Factor (PhD thesis). University of California, Berkeley. OCLC 29422094. ProQuest 302395896.
  8. Achtman, M; Willetts, N; Clark, A. J. (1971). "Beginning a genetic analysis of conjugational transfer determined by the F factor in Escherichia coli by isolation and characterization of transfer-deficient mutants". Journal of Bacteriology. 106 (2): 529–38. doi:10.1128/JB.106.2.529-538.1971. PMC 285127. PMID 4929865.
  9. Didelot, X; Pang, B; Zhou, Z; McCann, A; Ni, P; Li, D; Achtman, M; Kan, B (2015). "The role of china in the global spread of the current cholera pandemic". PLOS Genetics. 11 (3): e1005072. doi:10.1371/journal.pgen.1005072. PMC 4358972. PMID 25768799.
  10. Zhou, Z; McCann, A; Weill, F. X.; Blin, C; Nair, S; Wain, J; Dougan, G; Achtman, M (2014). "Transient Darwinian selection in Salmonella enterica serovar Paratyphi a during 450 years of global spread of enteric fever". Proceedings of the National Academy of Sciences of the United States of America. 111 (33): 12199–204. doi:10.1073/pnas.1411012111. PMC 4143038. PMID 25092320.
  11. Achtman, M.; Wain, J.; Weill, F. O. X.; Nair, S.; Zhou, Z.; Sangal, V.; Krauland, M. G.; Hale, J. L.; Harbottle, H.; Uesbeck, A.; Dougan, G.; Harrison, L. H.; Brisse, S.; S. Enterica MLST Study Group (2012). Bessen, Debra E (ed.). "Multilocus Sequence Typing as a Replacement for Serotyping in Salmonella enterica". PLOS Pathogens. 8 (6): e1002776. doi:10.1371/journal.ppat.1002776. PMC 3380943. PMID 22737074.
  12. Reuter, S; Connor, T. R.; Barquist, L; Walker, D; Feltwell, T; Harris, S. R.; Fookes, M; Hall, M. E.; Petty, N. K.; Fuchs, T. M.; Corander, J; Dufour, M; Ringwood, T; Savin, C; Bouchier, C; Martin, L; Miettinen, M; Shubin, M; Riehm, J. M.; Laukkanen-Ninios, R; Sihvonen, L. M.; Siitonen, A; Skurnik, M; Falcão, J. P.; Fukushima, H; Scholz, H. C.; Prentice, M. B.; Wren, B. W.; Parkhill, J; et al. (2014). "Parallel independent evolution of pathogenicity within the genus Yersinia". Proceedings of the National Academy of Sciences. 111 (18): 6768–73. doi:10.1073/pnas.1317161111. PMC 4020045. PMID 24753568.
  13. Mark Achtman on the Plague on YouTube
  14. Parkhill, J.; Achtman, M.; James, K. D.; Bentley, S. D.; Churcher, C.; Klee, S. R.; Morelli, G.; Basham, D.; Brown, D.; Chillingworth, T.; Davies, R. M.; Davis, P.; Devlin, K.; Feltwell, T.; Hamlin, N.; Holroyd, S.; Jagels, K.; Leather, S.; Moule, S.; Mungall, K.; Quail, M. A.; Rajandream, M. -A.; Rutherford, K. M.; Simmonds, M.; Skelton, J.; Whitehead, S.; Spratt, B. G.; Barrell, B. G. (2000). "Complete DNA sequence of a serogroup a strain of Neisseria meningitidis Z2491". Nature. 404 (6777): 502–6. doi:10.1038/35006655. PMID 10761919.
  15. Falush, D; Wirth, T; Linz, B; Pritchard, J. K.; Stephens, M; Kidd, M; Blaser, M. J.; Graham, D. Y.; Vacher, S; Perez-Perez, G. I.; Yamaoka, Y; Mégraud, F; Otto, K; Reichard, U; Katzowitsch, E; Wang, X; Achtman, M; Suerbaum, S (2003). "Traces of human migrations in Helicobacter pylori populations". Science. 299 (5612): 1582–5. doi:10.1126/science.1080857. PMID 12624269.
  16. Parkhill, J.; Sebaihia, M.; Preston, A.; Murphy, L. D.; Thomson, N.; Harris, D. E.; Holden, M. T. G.; Churcher, C. M.; Bentley, S. D.; Mungall, K. L.; Cerdeño-Tárraga, A. M.; Temple, L.; James, K.; Harris, B.; Quail, M. A.; Achtman, M.; Atkin, R.; Baker, S.; Basham, D.; Bason, N.; Cherevach, I.; Chillingworth, T.; Collins, M.; Cronin, A.; Davis, P.; Doggett, J.; Feltwell, T.; Goble, A.; Hamlin, N.; et al. (2003). "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica". Nature Genetics. 35 (1): 32–40. doi:10.1038/ng1227. PMID 12910271.
  17. Maiden, M. C.; Bygraves, J. A.; Feil, E; Morelli, G; Russell, J. E.; Urwin, R; Zhang, Q; Zhou, J; Zurth, K; Caugant, D. A.; Feavers, I. M.; Achtman, M; Spratt, B. G. (1998). "Multilocus sequence typing: A portable approach to the identification of clones within populations of pathogenic microorganisms". Proceedings of the National Academy of Sciences of the United States of America. 95 (6): 3140–5. doi:10.1073/pnas.95.6.3140. PMC 19708. PMID 9501229.
  18. "UK Government Research Grants awarded to Mark Achtman". Research Councils UK. Archived from the original on 13 May 2015.

Geneticist

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