Matthew P. Scott

Dr. Matthew P. Scott was the tenth president of the Carnegie Institution for Science.

Matthew P. Scott
CitizenshipUnited States
Alma materM.I.T.
Known forHomeobox discovery
Spouse(s)Margaret T. Fuller
Scientific career
FieldsDevelopmental biology
InstitutionsStanford University Carnegie Institution for Science
Doctoral advisorMary Lou Pardue
Notable studentsSean B. Carroll, Chris Q. Doe

While at Stanford University Dr. Scott studied how embryonic and later development is governed by proteins that control gene activity and cell signaling processes.[1] [2]

He independently discovered homeobox genes in Drosophila melanogaster working with Amy J. Weiner at Indiana University.[3][4]

Among his laboratory's many subsequent discoveries, he is recognized for the cloning of the patched gene family and demonstration that a human homolog PTCH1 is a key tumor suppressor gene for the Hedgehog signaling pathway as well as the causative gene for the nevoid basal cell carcinoma syndrome, or Gorlin syndrome.[5][6]

Biography

Scott served on the faculty of the Department of Molecular, Cellular, and Developmental Biology at the University of Colorado starting in 1983. He moved to Stanford University in 1990 to join the faculty of the Department of Developmental Biology and the Department of Genetics. From 2002-2007 he was Chair of Bio-X, Stanford's interdisciplinary biosciences program.[7]

He is married to Stanford developmental geneticist Margaret T. Fuller.

Awards

References
  1. "Scott lab homepage at Stanford University". Retrieved 2009-04-10.
  2. "HHMI Scientist Bio: Matthew P. Scott, Ph.D." Retrieved 2009-04-10.
  3. Scott, M. P. (1984). "Structural Relationships among Genes That Control Development: Sequence Homology between the Antennapedia, Ultrabithorax, and Fushi Tarazu Loci of Drosophila". Proceedings of the National Academy of Sciences. 81 (13): 4115–4119. doi:10.1073/pnas.81.13.4115. PMC 345379. PMID 6330741.
  4. Laughon, A.; Scott, M. P. (1984). "Sequence of a Drosophila segmentation gene: Protein structure homology with DNA-binding proteins". Nature. 310 (5972): 25–31. doi:10.1038/310025a0. PMID 6330566.
  5. Hooper, J. E.; Scott, M. P. (1989). "The Drosophila patched gene encodes a putative membrane protein required for segmental patterning". Cell. 59 (4): 751–765. doi:10.1016/0092-8674(89)90021-4. PMID 2582494.
  6. Johnson, R. L.; Rothman, A. L.; Xie, J.; Goodrich, L. V.; Bare, J. W.; Bonifas, J. M.; Quinn, A. G.; Myers, R. M.; Cox, D. R.; Epstein, E. H. Jr.; Scott, M. P. (1996). "Human homolog of patched, a candidate gene for the basal cell nevus syndrome". Science. 272 (5268): 1668–1671. doi:10.1126/science.272.5268.1668. PMID 8658145.
  7. "Biography: Matthew Scott". Center for Genetic Medicine, Northwestern University. Archived from the original on 2010-06-20. Retrieved 2009-04-10.
  8. "Scholar Profile, Matthew P. Scott". Searle Scholars program. Retrieved 2009-04-10.
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