Matthias Hentze

Matthias Werner Hentze (born 25 January 1960 in Wiedenbrück, Germany) is a German scientist. He is the Director of the European Molecular Biology Laboratory (EMBL)[4] and Professor of Molecular Medicine at Heidelberg University.[5]

Matthias Hentze
Born (1960-01-25) 25 January 1960
Wiedenbrück, Germany[1]
NationalityGerman
CitizenshipGerman
Alma materWestfälische Wilhelms-Universität Münster
Scientific career
FieldsMolecular Biology, RNA-binding proteins
Institutions
Thesis"Influence of amino acid analogs on maturation, transport and stability of cathepsin D in human skin fibroblasts" (1984)
Websitewww.embl.de

Biography

Matthias Hentze studied medicine in the UK at the medical schools at the universities of Southampton, Oxford, Glasgow and Cambridge, and in Germany at the Westfälische Wilhelms-Universität, Münster from which he qualified in 1984.[1] In the same year, he received his M.D. degree for a dissertation on the role of glycosylation in lysosomal enzyme expression with Kurt von Figura as his advisor.[1][6]

After a short phase of clinical work Hentze became a postdoctoral fellow at the National Institutes of Health (Bethesda, Maryland, USA) in 1985, having been awarded a fellowship by the German Research Foundation (DFG).[1] In 1989, he joined the European Molecular Biology Laboratory in Heidelberg as an independent group leader. At the age of 30, he obtained the Habilitation from the Ruprecht-Karls University in Heidelberg and was appointed Dean of the EMBL International Ph.D. Programme in 1996.[1]

Together with Prof. Andreas Kulozik of the Medical Faculty of Heidelberg University, Hentze co-founded the Molecular Medicine Partnership Unit (MMPU) in 2002[7][8] and serves as its Co-Director.[1] The MMPU represents the first institutional partnership between EMBL and a national research institution and is devoted to interdisciplinary research at the interface between molecular biology and clinical medicine.

In 2005, Hentze became Associate Director of the EMBL and Professor for Molecular Medicine at the University of Heidelberg.[1] In 2013, Hentze was appointed Director of EMBL, advising and supporting EMBL's Director General, Edith Heard.[4]

He is married and has three daughters. He regularly participates in marathons of the World Marathon Majors series.[9]

Research

Hentze’s research focuses on RNA biology and RNA-binding proteins. In 1987, Hentze and his colleagues discovered iron-responsive elements as first example of an RNA element regulating the translation of mammalian mRNA into proteins.[10] Hentze’s research group has paved the way for understanding translational control (RNA-binding proteins, microRNAs) whose significance for developmental biology, brain function, carcinogenesis and other diseases has in the meantime become widely recognized.[11] Moreover, he has made key discoveries in the area of iron metabolism and disease. [12]

In 2010, Hentze proposed the concept of REM Networks, a new interconnection between metabolism and gene expression on the basis of RNA-binding proteins.[13] The research project was awarded the ERC Advanced Investigator Grant by the European Research Council in 2011.[14] Work following this hypothesis led to the development of the “RNA Interactome Capture” technique and to the discovery of hundreds of formerly unknown RNA-binding proteins in the cells of living organisms from human to yeast, including more than 50 metabolic enzymes.[15][16][17]

Recently, Hentze and his colleagues discovered new RNA-binding motives of proteins which they unraveled using a newly developed method called “RBDmap”.[18] In 2019, they described the concept of riboregulation. They found out that the autophagy receptor protein p62 is directly regulated by a small RNA, vtRNA1-1.[19] Currently, their research focuses on how widely biological processes are riboregulated.

Honors and awards


Editorial Boards

Presently, Hentze is an Editorial Board member of several well-known, international scientific journals including Molecular Cell,[36] RNA,[37] EMBO Molecular Medicine,[38] Trends in Biochemical Sciences,[39] Journal of Molecular Medicine,[40] BMC Molecular Biology,[41] and Wiley Interdisciplinary Reviews: RNA.[42]

Other Activities

Hentze is or was a member of numerous international supervisory boards including the Scientific Advisory Board and Board of Trustees of the Max Delbrück Center for Molecular Medicine[43] (Berlin, Germany), the scientific advisory board of the Berlin Institute of Health (BIH/BIG),[44] the Istituto Nazionale Genetica Molecolare (INGM)[45] (Milano, Italy), the Centenary Institute[46] (Sydney, Australia) and the Cold Spring Harbor Conferences Asia.[47] Furthermore, Hentze is the scientific co-founder of Anadys Pharmaceuticals[48] (San Diego, USA).

Publications

Hentze is (co-)author of textbooks about Molecular Medicine and has published over 250 scientific original contributions.[1]

References
  1. Leopoldina CV. Retrieved 2020-07-30.
  2. National Institutes of Health Retrieved 2015-08-06.
  3. EMBL Homepage Archived 2008-11-13 at the Wayback Machine Retrieved 2015-08-06.
  4. EMBL Leadership. Retrieved 2015-06-12.
  5. Faculty at Heidelberg University Hospital. Retrieved 2015-06-12.
  6. Hentze, M.; Hasilik, A.; Figura, Kurt v. (1984). "Enhanced degradation of Cathepsin D synthesized in the presence of the threonine analog beta-hydroxynorvaline". Arch. Biochem. Biophys. 230 (1): 375–82. doi:10.1016/0003-9861(84)90120-6. PMID 6424571. Retrieved 2015-08-06.
  7. Smaglik, P (15 May 2003). "Language lessons: Heidelberg". Nature. 423 (6937): 364–5. doi:10.1038/nj6937-364a. PMID 12748657. S2CID 4416590.
  8. Joint Press Release. Molecular Medicine Partnership Unit initiates second phase. Retrieved 2020-07-30.
  9. Abbott World Marathon Majors Homepage/Claim results. Retrieved 2020-07-28
  10. Hentze, MW; Caughman, SW; Rouault, TA; Barriocanal, JG; Dancis, A; Harford, JB; Klausner, RD (1987). "Identification of the iron-responsive element for the translational regulation of human ferritin mRNA". Science. 238 (4833): 1570–73. Bibcode:1987Sci...238.1570H. doi:10.1126/science.3685996. PMID 3685996.
  11. Sonenberg, N; Hinnebusch, A (2007-12-14). "New modes of translational control in development, behavior, and disease". Mol Cell. 28 (5): 721–29. doi:10.1016/j.molcel.2007.11.018. PMID 18082597.
  12. Hentze, MW; Muckenthaler, MU; Galy, B; Camaschella, C (2010-07-09). "Two to tango: regulation of mammalian iron metabolism". Cell. 142 (1): 24–38. doi:10.1016/j.cell.2010.06.028. PMID 20603012. S2CID 23971474.
  13. Hentze, MW; Preiss, T (2010). "The REM phase of gene regulation". Trends Biochem Sci. 35 (8): 423–26. doi:10.1016/j.tibs.2010.05.009. PMID 20554447.
  14. Exploring the interface between cell metabolism and gene regulation: from mRNA interactomes to "REM Networks". European Commission/CORDIS EU Research results. Retrieved 2020-07-29.
  15. Castello, A; Fischer, B; Schuschke, K; Horos, R; Beckmann, BM; Strein, C; Davey, NE; Humphreys, DT; Preiss, T; Steinmetz, LM; Krijgsveld, J; Hentze, MW (2016-06-08). "Insights into RNA biology from an atlas of mammalian mRNA-binding proteins". Cell. 149 (6): 1393–1406. doi:10.1016/j.cell.2012.04.031. PMID 22658674. S2CID 17912260.
  16. Beckmann, BM; Horos, R; Fischer, B; Castello, A; Eichelbaum, K; Alleaume, AM; Schwarzl, T; Curk, T; Foehr, S; Huber, W; Krijgsveld, J; Hentze, MW (2015-12-03). "The RNA-binding proteomes from yeast to man harbor conserved enigmRBPs". Nature Communications. 6 (1012): 10127. Bibcode:2015NatCo...610127B. doi:10.1038/ncomms10127. PMC 4686815. PMID 26632259.
  17. Hentze, MW; Castello, A; Schwarzl, T; Preiss, T (2018-01-17). "A brave new world of RNA-binding proteins" (PDF). Nat Rev Mol Cell Biol. 19 (5): 327–41. doi:10.1038/nrm.2017.130. PMID 29339797. S2CID 4938952.
  18. Castello, A; Fischer, B; Frese, CK; Horos, R; Alleaume, AM; Foehr, S; Curk, T; Krijgsveld, J; Hentze, MW (2016-08-18). "Comprehensive identification of RNA-binding domains in human cells". Mol. Cell. 63 (4): 696–710. doi:10.1016/j.molcel.2016.06.029. PMC 5003815. PMID 27453046.
  19. Horos, R; Büscher, M; Kleinendorst, R; Alleaume, AM; Tarafder, AK; Schwarzl, T; Dziuba, D; Tischer, C; Zielonka, EM; Adak, A; Castello, A; Huber, W; Sachse, C; Hentze, MW (2019-02-21). "The Small Non-coding Vault RNA1-1 Acts as a Riboregulator of Autophagy". Cell. 176 (5): 1054–67. doi:10.1016/j.cell.2019.01.030. PMID 30773316. S2CID 72333202.
  20. 2020 RNA Society Lifetime Achievement Award. Retrieved 2020-07-30.
  21. Ilse & Helmut Wachter Awardee 2018. Retrieved 2020-07-30.
  22. American Academy of Arts and Sciences. Newly Elected Fellows. Retrieved 2018-05-15.
  23. Honorary Degree citation: Professor Matthias Hentze MD. Retrieved 2020-02-06.
  24. Australian Academy of Science/News and events. Retrieved 2018-07-30.
  25. "Profile: Hentze Matthias". Academy of Europe. Retrieved 7 September 2017.
  26. 66th Mosbacher Kolloquium 2015. Retrieved 2015-06-12. Archived 2015-06-02 at Archive.today
  27. Biospektrum.de. Retrieved 2015-07-20.
  28. RNA Society. Directors. Retrieved 2016-04-04
  29. ERC Investigator Grant 2011. List of Principal Investigators. Retrieved 2020-07-30.
  30. Lautenschläger-Research Prize 2007 for Prof. Dr. Matthias Hentze and Prof. Dr. Andreas Kulozik. Retrieved 2015-06-12.
  31. Biotechnology and Life Sciences in Baden-Württemberg. Retrieved 2015-07-20. Archived 2015-04-05 at the Wayback Machine
  32. Leopoldina. Nationale Akadamie der Wissenschaften. List of Members. Retrieved 2020-07-30.
  33. DFG German Research Foundation. Retrieved 2015-06-12.
  34. Gottfried Wilhelm Leibniz Programme 2000. Retrieved 2015-07-20.
  35. EMBO Membership Directory. Retrieved 2015-07-20.
  36. Cell Editorial Board. Retrieved 2015-07-20.
  37. RNA Editorial Board. Retrieved 2015-07-20
  38. EMBO Press - Editors & Advisory Editorial Board. Retrieved 2015-07-20.
  39. TiBS Editorial Board. Retrieved 2015-07-20.
  40. Journal of Molecular Medicine Editorial Board. Retrieved 2015-07-20.
  41. BMC Molecular Biology Editorial Board. Retrieved 2015-07-20.
  42. "Issue information". Wiley Interdisciplinary Reviews: RNA. 6 (1). 2014. doi:10.1002/wrna.1275. S2CID 222188869.
  43. MDC Research Report 2014. Page 321. Retrieved 2020-07-30.
  44. Press Release No. 1. March 12, 2014 / Berlin. Retrieved 2020-07-30.
  45. Comitato Tecnico Scientifico. INGM Homepage. Retrieved 2020-07-30.
  46. Scientific Advisory Board. Centenary Homepage. Retrieved 2020-07-30.
  47. CSH Asia Scientific Advisory Board (2013-2015) CSH Asia Homepage. Oversight&SAB. Retrieved 2020-07-30.
  48. Press Release. Anadys Pharmaceuticals Created. Retrieved 2020-07-30.
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