Monocytopenia

Monocytopenia is a form of leukopenia associated with a deficiency of monocytes. The causes of monocytopenia include: acute infections, stress, treatment with glucocorticoids, aplastic anemia, hairy cell leukemia, acute myeloid leukemia, treatment with myelotoxic drugs and genetic syndromes, as for example MonoMAC syndrome.[1]

Monocytopenia
SpecialtyHematology

It has been proposed as a measure to predict neutropenia,[2] though some research indicates that it is less effective than lymphopenia.[3]


Causes

Some of the causes are:

- acute infections

- stress

- treatment with glucocorticoids

- aplastic anemia

- hairy cell leukemia

- acute myeloid leukemia

- treatment with myelotoxic drugs

- genetic syndromes (e.g.: MonoMAC syndrome)

Diagnosis

- Blood Test (CBC) (Normal range of Monocytes: 1-10%) (Normal range in males: 0.2-0.8 x 10 3 /microliter)

- Blood test checking for monocypenia (Abnormal ranges: <1%) (Abnormal range in males: <0.2 10 3 /microliter)

References
  1. Harrison's principles of internal medicine. New York: McGraw-Hill. 2005. pp. 356. ISBN 978-0-07-140235-4.
  2. Kondo M, Oshita F, Kato Y, Yamada K, Nomura I, Noda K (1999). "Early monocytopenia after chemotherapy as a risk factor for neutropenia". Am. J. Clin. Oncol. 22 (1): 103–5. doi:10.1097/00000421-199902000-00025. PMID 10025393.
  3. Oguz A, Karadeniz C, Ckitak EC, Cil V (2006). "Which one is a risk factor for chemotherapy-induced febrile neutropenia in childhood solid tumors: early lymphopenia or monocytopenia?". Pediatr Hematol Oncol. 23 (2): 143–51. doi:10.1080/08880010500457673. PMID 16651243. S2CID 35305292.
Classification


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