N-acetylphosphatidylethanolamine-hydrolysing phospholipase D
N-acetylphosphatidylethanolamine-hydrolysing phospholipase D (EC 3.1.4.54, NAPE-PLD, anandamide-generating phospholipase D, N-acyl phosphatidylethanolamine phospholipase D, NAPE-hydrolyzing phospholipase D) is an enzyme with systematic name N-acetylphosphatidylethanolamine phosphatidohydrolase.[1][2] This enzyme catalyses the following chemical reaction
- N-acylphosphatidylethanolamine + H2O N-acylethanolamine + a 1,2-diacylglycerol 3-phosphate
| N-acetylphosphatidylethanolamine-hydrolysing phospholipase D | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.4.54 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme is involved in the biosynthesis of anandamide.
References
- Okamoto Y, Morishita J, Tsuboi K, Tonai T, Ueda N (February 2004). "Molecular characterization of a phospholipase D generating anandamide and its congeners". The Journal of Biological Chemistry. 279 (7): 5298–305. doi:10.1074/jbc.M306642200. PMID 14634025.
- Wang J, Okamoto Y, Morishita J, Tsuboi K, Miyatake A, Ueda N (May 2006). "Functional analysis of the purified anandamide-generating phospholipase D as a member of the metallo-beta-lactamase family". The Journal of Biological Chemistry. 281 (18): 12325–35. doi:10.1074/jbc.M512359200. PMID 16527816.
- Magotti, Paola; Bauer, Inga; Igarashi, Miki; Babagoli, Masih; Marotta, Roberto; Piomelli, Daniele; Garau, Gianpiero (March 2015). "Structure of Human N -Acylphosphatidylethanolamine-Hydrolyzing Phospholipase D: Regulation of Fatty Acid Ethanolamide Biosynthesis by Bile Acids". Structure. 23 (3): 598–604. doi:10.1016/j.str.2014.12.018. PMC 4351732. PMID 25684574.
External links
- N-acetylphosphatidylethanolamine-hydrolysing+phospholipase+D at the US National Library of Medicine Medical Subject Headings (MeSH)
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.