NPW

NPW is a gene that in humans encodes Neuropeptide W protein.[5][6][7]

NPW
Identifiers
Aliases	NPW, L8, L8C, PPL8, PPneuropeptide W
External IDs	OMIM: 607997 MGI: 2685781 HomoloGene: 17727 GeneCards: NPW
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 2,009,926 bp[1] End 2,020,755 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 24,657,330 bp[2] End 24,658,457 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • G-protein coupled receptor binding Cellular component • extracellular region Biological process • neuropeptide signaling pathway • feeding behavior • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	283869	381073
Ensembl	ENSG00000183971	ENSMUSG00000071230
UniProt	Q8N729	n/a
RefSeq (mRNA)	NM_001099456	NM_001099664
RefSeq (protein)	NP_001092926	n/a
Location (UCSC)	Chr 16: 2.01 – 2.02 Mb	Chr 17: 24.66 – 24.66 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Neuropeptide W (NPW) is an endogenous peptide ligand for GPR8 (MIM 600731), a G protein-coupled receptor.[supplied by OMIM][7]

References

1. GRCh38: Ensembl release 89: ENSG00000183971 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000071230 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fujii R, Yoshida H, Fukusumi S, Habata Y, Hosoya M, Kawamata Y, Yano T, Hinuma S, Kitada C, Asami T, Mori M, Fujisawa Y, Fujino M (Sep 2002). "Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7". J Biol Chem. 277 (37): 34010–6. doi:10.1074/jbc.M205883200. PMID 12118011.
6. Brezillon S, Lannoy V, Franssen JD, Le Poul E, Dupriez V, Lucchetti J, Detheux M, Parmentier M (Jan 2003). "Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8". J Biol Chem. 278 (2): 776–83. doi:10.1074/jbc.M206396200. PMID 12401809.
7. "Entrez Gene: NPW neuropeptide W".

Further reading

• Singh G, Davenport AP (2006). "Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system". Br. J. Pharmacol. 148 (8): 1033–41. doi:10.1038/sj.bjp.0706825. PMC 1752024. PMID 16847439.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Shimomura Y, Harada M, Goto M, et al. (2002). "Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8". J. Biol. Chem. 277 (39): 35826–32. doi:10.1074/jbc.M205337200. PMID 12130646.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tanaka H, Yoshida T, Miyamoto N, et al. (2003). "Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6251–6. doi:10.1073/pnas.0837789100. PMC 156358. PMID 12719537.
• Mondal MS, Yamaguchi H, Date Y, et al. (2003). "A role for neuropeptide W in the regulation of feeding behavior". Endocrinology. 144 (11): 4729–33. doi:10.1210/en.2003-0536. PMID 12959997.
• Mazzocchi G, Rebuffat P, Ziolkowska A, et al. (2005). "G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades". J. Clin. Endocrinol. Metab. 90 (6): 3466–71. doi:10.1210/jc.2004-2132. PMID 15797961.
• Andreis PG, Rucinski M, Neri G, et al. (2006). "Neuropeptides B and W enhance the growth of human adrenocortical carcinoma-derived NCI-H295 cells by exerting MAPK p42/p44-mediated proliferogenic and antiapoptotic effects". Int. J. Mol. Med. 16 (6): 1021–8. doi:10.3892/ijmm.16.6.1021. PMID 16273281.
• Mondal MS, Yamaguchi H, Date Y, et al. (2006). "Neuropeptide W is present in antral G cells of rat, mouse, and human stomach". J. Endocrinol. 188 (1): 49–57. doi:10.1677/joe.1.06195. PMID 16394174.