Neridronic acid

Neridronic acid (INN; the anion is called neridronate) is a bisphosphonate. In Italy it is used to treat Osteogenesis imperfecta and Paget's disease of bone.[1]

Neridronic acid

Clinical data
ATC code	none
Identifiers
IUPAC name (6-Amino-1-hydroxyhexane-1,1-diyl)bis(phosphonic acid)
CAS Number	79778-41-9
PubChem CID	71237
ChemSpider	64372
UNII	8U27U3RIN4
ECHA InfoCard	100.163.818
Chemical and physical data
Formula	C6H17NO7P2
Molar mass	277.150 g·mol^−1
3D model (JSmol)	Interactive image
SMILES C(CCC(O)(P(=O)(O)O)P(=O)(O)O)CCN
InChI InChI=1S/C6H17NO7P2/c7-5-3-1-2-4-6(8,15(9,10)11)16(12,13)14/h8H,1-5,7H2,(H2,9,10,11)(H2,12,13,14) Key:PUUSSSIBPPTKTP-UHFFFAOYSA-N
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A 2013 clinical trial suggests CRPS Type I (Complex regional pain syndrome) responds to treatment with intravenous neridronate.[2]

References

1. Gatti D, Viapiana O, Idolazzi L, Fracassi E, Adami S. "Neridronic acid for the treatment of bone metabolic diseases". Expert Opin Drug Metab Toxicol. 5: 1305–11. doi:10.1517/17425250903029190. PMID 19761412.
2. Varenna M, Adami S, Rossini M, et al. (March 2013). "Treatment of complex regional pain syndrome type I with neridronate: a randomized, double-blind, placebo-controlled study". Rheumatology. 52 (3): 534–42. doi:10.1093/rheumatology/kes312. PMID 23204550.