Neurolysin

Neurolysin (EC 3.4.24.16, neurotensin endopeptidase, endopeptidase 24.16, endo-oligopeptidase B (proline-endopeptidase)) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Preferential cleavage in neurotensin: Pro¹⁰-Tyr

This enzyme belongs to the peptidase family M3.

References

Checler F, Vincent JP, Kitabgi P (August 1986). "Purification and characterization of a novel neurotensin-degrading peptidase from rat brain synaptic membranes". The Journal of Biological Chemistry. 261 (24): 11274–81. PMID 3525564.
Barelli H, Vincent JP, Checler F (August 1988). "Peripheral inactivation of neurotensin. Isolation and characterization of a metallopeptidase from rat ileum". European Journal of Biochemistry. 175 (3): 481–9. doi:10.1111/j.1432-1033.1988.tb14220.x. PMID 3409880.
Checler F, Barelli H, Vincent JP (January 1989). "Tissue distribution of a novel neurotensin-degrading metallopeptidase. An immunological approach using monospecific polyclonal antibodies". The Biochemical Journal. 257 (2): 549–54. PMC 1135613. PMID 2649078.

Neurolysin at the US National Library of Medicine Medical Subject Headings (MeSH)

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

Proteases: metalloendopeptidases (EC 3.4.24)
ADAM proteins	Alpha secretases ADAM9 ADAM10 ADAM17 ADAM19 ADAM2 ADAM7 ADAM8 ADAM11 ADAM12 ADAM15 ADAM18 ADAM22 ADAM23 ADAM28 ADAM33 ADAMTS1 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADAMTS10 ADAMTS12 ADAMTS13
Matrix metalloproteinases	Collagenases MMP1 MMP8 Gelatinases MMP2 MMP9 MMP3 MMP7 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP20 MMP21 MMP23A MMP23B MMP24 MMP25 MMP26 MMP27 MMP28
Other	Neprilysin Procollagen peptidase Thermolysin Pregnancy-associated plasma protein A Bone morphogenetic protein 1 Lysostaphin Insulin-degrading enzyme ZMPSTE24

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)