PAQR8

Membrane progesterone receptor beta (mPRβ), or progestin and adipoQ receptor 8 (PAQR8), is a protein that in humans is encoded by the PAQR8 gene.[5][6][7]

PAQR8
Identifiers
Aliases	PAQR8, C6orf33, LMPB1, MPRB, progestin and adipoQ receptor family member 8
External IDs	OMIM: 607780 MGI: 1921479 HomoloGene: 32702 GeneCards: PAQR8
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p12.2 Start 52,361,421 bp[1] End 52,407,777 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 A4 Start 20,890,606 bp[2] End 20,939,650 bp[2]
Gene ontology Molecular function • steroid hormone receptor activity • steroid binding • lipid binding • signaling receptor activity Cellular component • integral component of membrane • membrane • Golgi apparatus • cell membrane Biological process • multicellular organism development • response to steroid hormone • cell differentiation • oogenesis • steroid hormone mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	85315	74229
Ensembl	ENSG00000170915	ENSMUSG00000025931
UniProt	Q8TEZ7	Q80ZE5
RefSeq (mRNA)	NM_133367	NM_028829 NM_001355122
RefSeq (protein)	NP_588608	NP_083105 NP_001342051
Location (UCSC)	Chr 6: 52.36 – 52.41 Mb	Chr 1: 20.89 – 20.94 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Membrane progesterone receptor
• Progestin and adipoQ receptor

References

1. GRCh38: Ensembl release 89: ENSG00000170915 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025931 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Suzuki T, Ganesh S, Agarwala KL, Morita R, Sugimoto Y, Inazawa J, Delgado-Escueta AV, Yamakawa K (Nov 2001). "A novel gene in the chromosomal region for juvenile myoclonic epilepsy on 6p12 encodes a brain-specific lysosomal membrane protein". Biochemical and Biophysical Research Communications. 288 (3): 626–36. doi:10.1006/bbrc.2001.5825. PMID 11676489.
6. Zhu Y, Rice CD, Pang Y, Pace M, Thomas P (Mar 2003). "Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes". Proceedings of the National Academy of Sciences of the United States of America. 100 (5): 2231–6. doi:10.1073/pnas.0336132100. PMC 151323. PMID 12574519.
7. "Entrez Gene: PAQR8 progestin and adipoQ receptor family member VIII".

Further reading

• Wistow G, Bernstein SL, Ray S, Wyatt MK, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (Jun 2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Molecular Vision. 8: 185–95. PMID 12107412.
• Zhu Y, Bond J, Thomas P (Mar 2003). "Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor". Proceedings of the National Academy of Sciences of the United States of America. 100 (5): 2237–42. Bibcode:2003PNAS..100.2237Z. doi:10.1073/pnas.0436133100. PMC 151324. PMID 12601167.
• Hammes SR (Mar 2003). "The further redefining of steroid-mediated signaling". Proceedings of the National Academy of Sciences of the United States of America. 100 (5): 2168–70. Bibcode:2003PNAS..100.2168H. doi:10.1073/pnas.0530224100. PMC 151311. PMID 12606724.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD (Sep 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–80. Bibcode:2005JMolE..61..372T. doi:10.1007/s00239-004-0375-2. PMID 16044242. S2CID 31473802.