PLRG1

Pleiotropic regulator 1 is a protein that in humans is encoded by the PLRG1 gene.[5]

PLRG1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4YVD
Identifiers
Aliases	PLRG1, Cwc1, PRL1, PRP46, PRPF46, TANGO4, pleiotropic regulator 1
External IDs	OMIM: 605961 MGI: 1858197 HomoloGene: 2004 GeneCards: PLRG1
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q31.3 Start 154,535,005 bp[1] End 154,550,400 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 E3 Start 83,055,522 bp[2] End 83,072,355 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • DNA replication factor A complex • Cul4-RING E3 ubiquitin ligase complex • catalytic step 2 spliceosome • not the membrane • spliceosomal complex • precatalytic spliceosome • Prp19 complex • fibrillar center • nucleoplasm • nuclear speck • U2-type catalytic step 2 spliceosome • cell nucleus Biological process • protein localization to nucleus • positive regulation of G1/S transition of mitotic cell cycle • mRNA processing • RNA splicing • mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5356	53317
Ensembl	ENSG00000171566	ENSMUSG00000027998
UniProt	O43660	Q922V4
RefSeq (mRNA)	NM_002669 NM_001201564	NM_016784
RefSeq (protein)	NP_001188493 NP_002660	NP_058064
Location (UCSC)	Chr 4: 154.54 – 154.55 Mb	Chr 3: 83.06 – 83.07 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

PLRG1 has been shown to interact with CDC5L.[6][7][8][9]

References

1. GRCh38: Ensembl release 89: ENSG00000171566 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027998 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: PLRG1 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)".
6. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
7. Ajuh P, Lamond AI (November 2003). "Identification of peptide inhibitors of pre-mRNA splicing derived from the essential interaction domains of CDC5L and PLRG1". Nucleic Acids Res. 31 (21): 6104–16. doi:10.1093/nar/gkg817. PMC 275459. PMID 14576297.
8. Ajuh P, Sleeman J, Chusainow J, Lamond AI (November 2001). "A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing". J. Biol. Chem. 276 (45): 42370–81. doi:10.1074/jbc.M105453200. ISSN 0021-9258. PMID 11544257.
9. Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.

Further reading

• Németh K, Salchert K, Putnoky P, et al. (1998). "Pleiotropic control of glucose and hormone responses by PRL1, a nuclear WD protein, in Arabidopsis". Genes Dev. 12 (19): 3059–73. doi:10.1101/gad.12.19.3059. PMC 317193. PMID 9765207.
• Ajuh P, Kuster B, Panov K, et al. (2001). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
• Ajuh P, Sleeman J, Chusainow J, Lamond AI (2001). "A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing". J. Biol. Chem. 276 (45): 42370–81. doi:10.1074/jbc.M105453200. PMID 11544257.
• Rappsilber J, Ryder U, Lamond AI, Mann M (2002). "Large-scale proteomic analysis of the human spliceosome". Genome Res. 12 (8): 1231–45. doi:10.1101/gr.473902. PMC 186633. PMID 12176931.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ajuh P, Lamond AI (2003). "Identification of peptide inhibitors of pre-mRNA splicing derived from the essential interaction domains of CDC5L and PLRG1". Nucleic Acids Res. 31 (21): 6104–16. doi:10.1093/nar/gkg817. PMC 275459. PMID 14576297.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.