Phospholipid transfer protein

Phospholipid transfer protein is a protein that in humans is encoded by the PLTP gene.

PLTP
Identifiers
AliasesPLTP, BPIFE, HDLCQ9, phospholipid transfer protein
External IDsMGI: 103151 HomoloGene: 4536 GeneCards: PLTP
Gene location (Human)
Chr.Chromosome 20 (human)[1]
Band20q13.12Start45,898,621 bp[1]
End45,912,155 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5360

18830

Ensembl

ENSG00000100979

ENSMUSG00000017754

UniProt

P55058

P55065

RefSeq (mRNA)

NM_182676
NM_001242920
NM_001242921
NM_006227

NM_011125

RefSeq (protein)

NP_001229849
NP_001229850
NP_006218
NP_872617

NP_035255

Location (UCSC)Chr 20: 45.9 – 45.91 MbChr 2: 164.84 – 164.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene.[5]

Interactions

PLTP has been shown to interact with Apolipoprotein A1[6] and APOA2.[6]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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|px|alt=Statin Pathway edit]]
Statin Pathway edit
  1. The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".

References

  1. GRCh38: Ensembl release 89: ENSG00000100979 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000017754 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: PLTP phospholipid transfer protein".
  6. Pussinen PJ, Jauhiainen M, Metso J, Pyle LE, Marcel YL, Fidge NH, Ehnholm C (Jan 1998). "Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: location of a PLTP binding domain in the amino terminal region of apoA-I". J. Lipid Res. 39 (1): 152–61. PMID 9469594.

Further reading


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