Pimelyl-(acyl-carrier protein) methyl ester esterase

Pimelyl-(acyl-carrier protein) methyl ester esterase (EC 3.1.1.85, BioH) is an enzyme with systematic name pimelyl-(acyl-carrier protein) methyl ester hydrolase.[1][2][3][4] This enzyme catalyses the following chemical reaction

pimelyl-[acyl-carrier protein] methyl ester + H2O pimelyl-[acyl-carrier protein] + methanol
Pimelyl-(acyl-carrier protein) methyl ester esterase
Identifiers
EC number3.1.1.85
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme takes part in biotin biosynthesis in Gram-negative bacteria.

References
  1. Sanishvili R, Yakunin AF, Laskowski RA, Skarina T, Evdokimova E, Doherty-Kirby A, Lajoie GA, Thornton JM, Arrowsmith CH, Savchenko A, Joachimiak A, Edwards AM (July 2003). "Integrating structure, bioinformatics, and enzymology to discover function: BioH, a new carboxylesterase from Escherichia coli". The Journal of Biological Chemistry. 278 (28): 26039–45. doi:10.1074/jbc.M303867200. PMC 2792009. PMID 12732651.
  2. Lemoine Y, Wach A, Jeltsch JM (February 1996). "To be free or not: the fate of pimelate in Bacillus sphaericus and in Escherichia coli". Molecular Microbiology. 19 (3): 645–7. doi:10.1046/j.1365-2958.1996.t01-4-442924.x. PMID 8830257.
  3. Tomczyk NH, Nettleship JE, Baxter RL, Crichton HJ, Webster SP, Campopiano DJ (February 2002). "Purification and characterisation of the BIOH protein from the biotin biosynthetic pathway". FEBS Letters. 513 (2–3): 299–304. doi:10.1016/s0014-5793(02)02342-6. PMID 11904168.
  4. Lin S, Hanson RE, Cronan JE (September 2010). "Biotin synthesis begins by hijacking the fatty acid synthetic pathway". Nature Chemical Biology. 6 (9): 682–8. doi:10.1038/nchembio.420. PMC 2925990. PMID 20693992.
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