Pindone

Pindone is an anticoagulant drug[3] for agricultural use. It is commonly used as a rodenticide in the management of rat and rabbit populations.

Pindone

Names
IUPAC name 2-(2,2-Dimethyl-1-oxopropyl)indane-1,3-dione
Other names 2-Pivaloyl-1,3-indandione
Identifiers
CAS Number	83-26-1
3D model (JSmol)	Interactive image
ChemSpider	6476
ECHA InfoCard	100.001.330
KEGG	C19141
PubChem CID	6732
UNII	2KFI1XBH7G
CompTox Dashboard (EPA)	DTXSID1025930
InChI InChI=1S/C14H14O3/c1-14(2,3)13(17)10-11(15)8-6-4-5-7-9(8)12(10)16/h4-7,10H,1-3H3 Key: RZKYEQDPDZUERB-UHFFFAOYSA-N InChI=1/C14H14O3/c1-14(2,3)13(17)10-11(15)8-6-4-5-7-9(8)12(10)16/h4-7,10H,1-3H3 Key: RZKYEQDPDZUERB-UHFFFAOYAX
SMILES O=C2c1ccccc1C(=O)C2C(=O)C(C)(C)C
Properties
Chemical formula	C14H14O3
Molar mass	230.26 g/mol
Appearance	Bright-yellow powder[1]
Odor	almost none
Density	1.06 g/mL
Melting point	110 °C (230 °F; 383 K)
Solubility in water	0.002% (25°C)[1]
Hazards
Lethal dose or concentration (LD, LC):
LD50 (median dose)	280 mg/kg (rat, oral) 75 mg/kg (dog, oral) 150 mg/kg (rabbit, oral)[2]
NIOSH (US health exposure limits):
PEL (Permissible)	TWA 0.1 mg/m^3[1]
REL (Recommended)	TWA 0.1 mg/m^3[1]
IDLH (Immediate danger)	100 mg/m^3[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

It is pharmacologically analogous to warfarin and inhibits the synthesis of Vitamin K-dependent clotting factors.

See also

• 1,3-Indandione

References

1. NIOSH Pocket Guide to Chemical Hazards. "#0516". National Institute for Occupational Safety and Health (NIOSH).
2. "Pindone". Immediately Dangerous to Life and Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).
3. Robinson MH, Twigg LE, Wheeler SH, Martin GR (March 2005). "Effect of the anticoagulant, pindone, on the breeding performance and survival of merino sheep, Ovis aries". Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 140 (3): 465–73. doi:10.1016/j.cbpc.2004.11.011. PMID 15694595.