Pyridinylpiperazine

1-(2-Pyridinyl)piperazine is a chemical compound and piperazine derivative. Some derivatives of this substance are known to act as potent and selective α₂-adrenergic receptor antagonists, such as 1-(3-fluoro-2-pyridinyl)piperazine.[1]

Pyridinylpiperazine

Names
IUPAC name 1-(pyridin-2-yl)piperazine
Identifiers
CAS Number	34803-66-2
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL18094
ChemSpider	85244
ECHA InfoCard	100.047.458
EC Number	252-220-3
PubChem CID	94459
UNII	5IO1HZP7ZN
CompTox Dashboard (EPA)	DTXSID90188341
InChI InChI=1S/C9H13N3/c1-2-4-11-9(3-1)12-7-5-10-6-8-12/h1-4,10H,5-8H2 Key: GZRKXKUVVPSREJ-UHFFFAOYSA-N InChI=1S/C9H13N3/c1-2-4-11-9(3-1)12-7-5-10-6-8-12/h1-4,10H,5-8H2 InChI=1S/C9H13N3/c1-2-4-11-9(3-1)12-7-5-10-6-8-12/h1-4,10H,5-8H2 Key: GZRKXKUVVPSREJ-UHFFFAOYSA-N
SMILES n1ccccc1N2CCNCC2
Properties
Chemical formula	C9H13N3
Molar mass	163.22 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

A few pyridinylpiperazine derivatives are drugs, including:

• Azaperone — antipsychotic
• Atevirdine — antiretroviral
• Delavirdine — antiretroviral
• Mirtazapine — antidepressant

See also

• Diphenylmethylpiperazine
• Benzylpiperazine
• Phenylpiperazine
• Pyrimidinylpiperazine

References

1. Saari WS, Halczenko W, King SW, et al. (December 1983). "Pyridinylpiperazines, a new class of selective alpha 2-adrenoceptor antagonists". Journal of Medicinal Chemistry. 26 (12): 1696–701. doi:10.1021/jm00366a007. PMID 6139479.