Pyrogallol hydroxytransferase
In enzymology, a pyrogallol hydroxytransferase (EC 1.97.1.2) is an enzyme that catalyzes the chemical reaction
- 1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene 1,3,5-trihydroxybenzene + 1,2,3,5-tetrahydroxybenzene
| pyrogallol hydroxytransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.97.1.2 | ||||||||
| CAS number | 125978-84-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 1,2,3,5-tetrahydroxybenzene and 1,2,3-trihydroxybenzene (pyrogallol), whereas its two products are 1,3,5-trihydroxybenzene (phloroglucinol) and 1,2,3,5-tetrahydroxybenzene.
This enzyme participates in benzoic acid degradation via CoA ligation.
Nomenclature
This enzyme belongs to the family of oxidoreductases. The systematic name of this enzyme class is 1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxytransferase. Other names in common use include 1,2,3,5-tetrahydroxybenzene hydroxyltransferase, 1,2,3,5-tetrahydroxybenzene:pyrogallol transhydroxylase, 1,2,3,5-tetrahydroxybenzene-pyrogallol hydroxyltransferase (transhydroxylase), pyrogallol hydroxyltransferase, 1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxyltransferase.
References
- Brune A, Schink B (February 1990). "Pyrogallol-to-phloroglucinol conversion and other hydroxyl-transfer reactions catalyzed by cell extracts of Pelobacter acidigallici". Journal of Bacteriology. 172 (2): 1070–6. doi:10.1128/jb.172.2.1070-1076.1990. PMC 208538. PMID 2298693.