RCL1

RNA 3'-terminal phosphate cyclase-like protein is an enzyme that in humans is encoded by the RCL1 gene.[5]

RCL1
Identifiers
Aliases	RCL1, RNAC, RPCL1, RNA terminal phosphate cyclase like 1
External IDs	OMIM: 611405 MGI: 1913275 HomoloGene: 4217 GeneCards: RCL1
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p24.1 Start 4,792,944 bp[1] End 4,885,917 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C1 Start 29,101,375 bp[2] End 29,143,929 bp[2]
Gene ontology Molecular function • catalytic activity • RNA-3'-phosphate cyclase activity • endoribonuclease activity Cellular component • cell nucleus • nucleoplasm • nucleolus Biological process • RNA processing • ribosome biogenesis • endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • rRNA processing • endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • biological process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10171	59028
Ensembl	ENSG00000120158	ENSMUSG00000024785
UniProt	Q9Y2P8	Q9JJT0
RefSeq (mRNA)	NM_001286699 NM_001286700 NM_001286701 NM_005772	NM_021525
RefSeq (protein)	NP_001273628 NP_001273629 NP_001273630 NP_005763	NP_067500
Location (UCSC)	Chr 9: 4.79 – 4.89 Mb	Chr 19: 29.1 – 29.14 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Fibrillarin
• Small nucleolar RNA U3
• RRP9
• UTP6
• UTP11L
• UTP14A
• UTP15

References

1. GRCh38: Ensembl release 89: ENSG00000120158 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024785 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: RCL1 RNA terminal phosphate cyclase-like 1".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–374. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–1560. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Billy E, Wegierski T, Nasr F, Filipowicz W (2000). "Rcl1p, the yeast protein similar to the RNA 3'-phosphate cyclase, associates with U3 snoRNP and is required for 18S rRNA biogenesis". EMBO J. 19 (9): 2115–2126. doi:10.1093/emboj/19.9.2115. PMC 305690. PMID 10790377.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Genschik P, Billy E, Swianiewicz M, Filipowicz W (1997). "The human RNA 3'-terminal phosphate cyclase is a member of a new family of proteins conserved in Eucarya, Bacteria and Archaea". EMBO J. 16 (10): 2955–2967. doi:10.1093/emboj/16.10.2955. PMC 1169903. PMID 9184239.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Vicente O, Filipowicz W (1988). "Purification of RNA 3'-terminal phosphate cyclase from HeLa cells. Covalent modification of the enzyme with different nucleotides". Eur. J. Biochem. 176 (2): 431–439. doi:10.1111/j.1432-1033.1988.tb14300.x. PMID 3416880.

External links

• RCL1 human gene location in the UCSC Genome Browser.
• RCL1 human gene details in the UCSC Genome Browser.