Renal oligopeptide reabsorption

Renal oligopeptide reabsorption is the part of renal physiology that deals with the retrieval of filtered oligopeptides, preventing them from disappearing from the body through the urine.

Almost all reabsorption takes place in the proximal tubule. Practically nothing is left in the final urine. Longer oligopeptides, such as angiotensin[1] and glutathione[1] are degraded by enzymes on the brush border, while shorter ones, such as carnosine,[1] are transported across the apical membrane as a whole by the PepT 1 transporter, and degraded inside the proximal tubule cell.

Overview table
Characteristics of oligopeptide reabsorption
Characteristic proximal tubule loop of Henle Distal convoluted tubule Collecting duct system
S1 S2 S3
reabsorption (%) 99[1] Beyond the proximal tubule: 1%[1]
reabsorption (mmoles/day)
Concentration
apical transport proteins
  • sodium-amino acid symporter[1]
  • PepT 1 (for short peptides, n=2 to 4)[1]
basolateral transport proteins
Other reabsorption features

References
  1. Walter F., PhD. Boron. Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. ISBN 1-4160-2328-3. Page 798
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