Roger Gosden

Roger Gordon Gosden (born 23 September 1948) is a British-American physiologist in the field of female reproductive medicine. His scientific research focused on understanding the basic biology of development and senescence of ovaries in women, including mathematically modeling those processes. He did important translational research on ovarian tissue cryopreservation and transplantation.

Roger Gordon Gosden

PhD DSc
Born (1948-09-23) 23 September 1948
Ryde, Isle of Wight
NationalityBritish & American
Alma materUniversity of Bristol
University of Cambridge
University of Edinburgh
Spouse(s)Lucinda Veeck Gosden
Scientific career
FieldsPhysiology
Reproductive medicine
InstitutionsUniversity of Cambridge
Duke University
Edinburgh Medical School
Leeds School of Medicine
McGill University Health Centre
Eastern Virginia Medical School
Weill Cornell Medical School
College of William & Mary
Theses
Doctoral advisorRobert Edwards

Early life and education

Gosden was born on 23 September 1948 at Ryde on the Isle of Wight,[1] the son of Gordon Gosden and Peggy Gosden, née Butcher.[2] He went to Chislehurst and Sidcup Grammar School in Sidcup, Kent,[3] and then took a BSc from the University of Bristol in 1970.[1] He did post-graduate work under Robert Edwards at Darwin College, Cambridge, where he graduated PhD in 1974 with a thesis on Reproductive senescence in female rodents.[4][5][6]

Scientific career

Gosden was a lecturer in physiology at the University of Edinburgh Medical School from 1976 to 1994,[2] a professor of reproductive sciences at Leeds School of Medicine from 1994 to 1999,[1] and scientific director of reproductive biology at McGill University Health Centre from 1999 to 2001.[3][7] His departure from the UK was the hook for an article in The Independent about a wave of scientists emigrating from the UK due to negative public opinion about scientists in the UK.[7] In 2001, Gosden became the director of scientific research at the Jones Institute for Reproductive Medicine at Eastern Virginia Medical School,[1] where he was named the Howard & Georgeanna Professor of Reproductive Medicine.[3] He left the Jones Institute in 2004 to become research director of reproductive biology at Weill Cornell Medicine, where his wife was on the faculty; part of the reason why Gosden left the institute was negative public opinion and criticism due to its creation in 2001 of an embryonic stem cell line, as was noted in a report in the journal, Science.[8] He retired from research in 2010.[9]

Gosden's research was focused on understanding, forecasting and treating infertility.[10] His work focused on understanding basic biology around development and senescence of ovarian follicles and ovaries in women, including trying to mathematically model those processes, and he did important translational research on ovarian tissue cryopreservation and on ovary transplantation; his interests also extended to uterus transplantation.[10][11] In 1994, Gosden and colleagues announced that they had successfully restored fertility to and achieved two live births in sheep through ovarian tissue autotransplantation, one of which had been frozen then thawed.[12] In collaboration with Sherman Silber, this technique was later extended to women using tissue or the entire ovary transplanted from an identical twin.[13][14][15][16] As of December 2016, there had been 86 live-births and were 9 on-going pregnancies directly as a result of these types of ovarian tissue transplantation.[17]

Gosden was a scientific advisor to Celmatix, Inc., which was founded by his former student.[18][19] He spoke out against the controversial claims made by OvaScience, a company founded in 2012, that it could help older women conceive using putative oogonial stem cells.[20]

Personal life

Gosden married Carole Ann Walsh in 1971 and they had two sons before their divorce in 2003.[1][3] In 2004 he married Lucinda Veeck, whom he had met at the Jones Institute in Norfolk when she was working there.[21][22][23] In the same year he moved to New York to work at Weill Cornell Medicine, where Veeck was director of clinical embryology.[8]

In 2010, they both moved to Williamsburg, Virginia, where they run an independent publishing company, Jamestowne Bookworks,[9] which Gosden opened as outlet for his own works, to allow him to control his own works after a life of assigning copyright to biomedical publishers, and to publish other people's work that interested him.[24]

Honours and lectures

Books
  • Biology of menopause: the causes and consequences of ovarian ageing. Academic Press, 1985. ISBN 9780122918506
  • (with Yves Aubard) Transplantation of Ovarian and Testicular Tissues. Chapman & Hall, 1996. ISBN 9780412105319
  • Cheating Time. W. H. Freeman, 1999. ISBN 9780716736486
  • Designing Babies: The Brave New World of Reproductive Technology, 2000. W.H. Freeman. ISBN 9780716741688
  • (with S.L. Tan) The Cryobiology of Assisted Reproduction: Gametes and Gonads. Seminars in reproductive medicine. Thieme, 2002. ISSN 1526-8004
  • (with Alan Trounson) Biology and Pathology of the Oocyte: Its Role in Fertility and Reproductive Medicine. Cambridge University Press, 2003. ISBN 9780521799584
  • (with Togas Tulandi) Preservation of Fertility. Taylor & Francis, 2004. ISBN 9781842142424
  • (with Alan Trounson and Ursula Eichenlaub-Ritter) Biology and Pathology of the Oocyte: Role in Fertility, Medicine and Nuclear Reprogramming. Cambridge University Press, 2013. ISBN 9781107021907

References
  1. Peacock, Scot (2004). Contemporary Authors, New Revision Series. Detroit, Michigan: Gale. pp. glish. ISBN 9780787692018. OCLC 527378529. Retrieved 6 February 2017 – via Encyclopedia.com.
  2. Lumley, Elizabeth (2002). The Canadian Who's Who. University of Toronto Press. p. 514. ISBN 9780802049704.
  3. Sleeman, Elizabeth; Neale, Alison; Robinson, Kate, eds. (2003). The International Who's Who 2004. London: Europa Publications Limited. ISBN 9781857432176. OCLC 491652781.
  4. Prentice, Andrew; Smith, Sophia; et al., eds. (2007). "New York alumni gathering". The Darwinian. Retrieved 6 February 2017 – via Issuu.com.
  5. Gosden, R.G. (21 May 1974). Reproductive senescence in female rodents (Thesis). University of Cambridge Department of Physiology.
  6. Johnson, MH (August 2011). "Robert Edwards: the path to IVF". Reproductive Biomedicine Online. 23 (2): 245–62. doi:10.1016/j.rbmo.2011.04.010. PMC 3171154. PMID 21680248.
  7. Dobson, Roger (26 September 1999). "Focus: The Brain Drain: Medical stars pack their bags". The Independent. Retrieved 11 February 2017.
  8. Science, American Association for the Advancement of (3 September 2004). "Random Samples". Science. 305 (5689): 1398. ISSN 0036-8075.
  9. Simpson, Elizabeth (8 October 2015). "Father of in-vitro fertilization delivers final story of medicine, love". Virginian-Pilot.
  10. Hillier, P. S. G. (1 February 2012). "Modern methods of fertility preservation: a tribute to Roger Gosden". Molecular Human Reproduction. 18 (2): 57–58. doi:10.1093/molehr/gas003. PMID 22287563.
  11. Gosden, RG (December 2008). "Ovary and uterus transplantation". Reproduction (Cambridge, England). 136 (6): 671–80. doi:10.1530/REP-08-0099. PMID 18728099.
  12. Prasath, Ethiraj B. (1 January 2008). "Ovarian tissue cryopreservation: An update". Journal of Human Reproductive Sciences. 1 (2): 50–55. doi:10.4103/0974-1208.44111. PMC 2700672. PMID 19562046.
  13. Silber, S. J. (1 February 2012). "Ovary cryopreservation and transplantation for fertility preservation". Molecular Human Reproduction. 18 (2): 59–67. doi:10.1093/molehr/gar082. PMID 22205727.
  14. Silber, S.J.; Gosden, R.G.; et al. (11 December 2008). "Successful pregnancy after microsurgical transplantation of an intact ovary". The New England Journal of Medicine. 359 (24): 2617–2618. doi:10.1056/NEJMc0804321. PMID 19073987.
  15. Lambert, Victoria (26 November 2009). "Fertility: stop all the clocks". Telegraph.co.uk. Archived from the original on 11 February 2017. Retrieved 11 February 2017.
  16. Cooperman, Jeannette (7 September 2012). "Dr. Sherman Silber Takes His Reproductive Technology to China". St. Louis Magazine. Archived from the original on 11 February 2017. Retrieved 11 February 2017.
  17. Jensen, A. K.; Macklon, K. T.; Fedder, J.; Ernst, E.; Humaidan, P.; Andersen, C. Y. (27 December 2016). "86 successful births and 9 ongoing pregnancies worldwide in women transplanted with frozen-thawed ovarian tissue: focus on birth and perinatal outcome in 40 of these children". Journal of Assisted Reproduction and Genetics. 34 (3): 325–336. doi:10.1007/s10815-016-0843-9. PMC 5360679. PMID 28028773.
  18. Mollory, Chris; Charlie, Grebenstein; et al. (2016). "Digital Healthcare - RSA Talent Equity Report". RSA Group: 23. Retrieved 8 February 2017.
  19. "Celmatix, Inc. - Relationship Science". Relationshipscience.com. Archived from the original on 8 February 2017. Retrieved 8 February 2017.
  20. Boyd, Roddy (6 April 2015). "Irreproducible Results, Inc". Southern Investigative Reporting Foundation.
  21. Simpson, Elizabeth (1 December 2014). "For in vitro pioneer, even at 103, the work never ends". Virginian-Pilot.
  22. Mundy, Liza (24 April 2007). Everything Conceivable. Knopf Doubleday Publishing Group. ISBN 9780307267276.
  23. Garcia, Jairo; Veeck, Lucinda; et al. (1984). "In vitro fertilization in Norfolk, Virginia, 1980–1983". Journal of in Vitro Fertilization and Embryo Transfer. 1 (1): 24–28. doi:10.1007/BF01129616. ISSN 0740-7769. PMID 6336088.
  24. Phelps, Linda Landreth (March 2015). "Dr. Roger Gosden: Scientist and Writer" (PDF). Williamsburgh's Next Door Neighbors. 9 (3): 21–23.
  25. "Past Awards - Society for Reproduction and Fertility". Society for Reproduction and Fertility. Archived from the original on 6 February 2017. Retrieved 6 February 2017.
  26. Campbell, Trudi (ed.). "Newsletter - Autumn 2013" (PDF). British Fertility Society. Bioscientifica Ltd. pp. 5, 7. ISSN 2045-6891.
  27. "XVth Development and Function of Reproductive Organs International Conference". University of St Andrews. Archived from the original on 6 February 2017. Retrieved 6 February 2017.
  28. Bronchart, Rudy Lechantre and Gregory. "Board Of Directors". International Society for Fertility Preservation. Archived from the original on 6 February 2017. Retrieved 6 February 2017.
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