Russellysin
Russellysin (EC 3.4.24.58, Russell's viper venom factor X activator, RVV-X, blood-coagulation factor X activating enzyme, metalloproteinase RVV-x, Vipera russelli proteinase, Russell's viper blood coagulation factor X activator, RVV-V) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Specifically activates several components of the blood clotting system, including coagulation factor X, coagulation factor IX and protein C by cleavage of -Arg- bonds. Has no action on insulin B chain
| Russellysin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.24.58 | ||||||||
| CAS number | 79393-92-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme is present in the venom of Russell's viper (Vipera russelli).
References
- Furie BC, Furie B (1976). "Coagulant protein of Russell's viper venom". Methods in Enzymology. 45: 191–205. doi:10.1016/s0076-6879(76)45019-x. PMID 1011991.
- Lindquist PA, Fujikawa K, Davie EW (March 1978). "Activation of bovine factor IX (Christmas factor) by factor XIa (activated plasma thromboplastin antecedent) and a protease from Russell's viper venom". The Journal of Biological Chemistry. 253 (6): 1902–9. PMID 632245.
- Takeya H, Nishida S, Miyata T, Kawada S, Saisaka Y, Morita T, Iwanaga S (July 1992). "Coagulation factor X activating enzyme from Russell's viper venom (RVV-X). A novel metalloproteinase with disintegrin (platelet aggregation inhibitor)-like and C-type lectin-like domains". The Journal of Biological Chemistry. 267 (20): 14109–17. PMID 1629211.
External links
- Russellysin at the US National Library of Medicine Medical Subject Headings (MeSH)
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