SLC12A9

Solute carrier family 12 member 9 (SLC12A9), also known as cation-chloride cotransporter 6 (CCC6) or cation-chloride cotransporter-interacting protein 1 (CIP1), is a protein that in humans is encoded by the SLC12A9 gene.[5][6][7]

SLC12A9
Identifiers
Aliases	SLC12A9, CCC6, CIP1, WO3.3, hCCC6, solute carrier family 12 member 9
External IDs	OMIM: 616861 MGI: 1933532 HomoloGene: 5429 GeneCards: SLC12A9
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1 Start 100,826,820 bp[1] End 100,867,010 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 137,314,558 bp[2] End 137,333,597 bp[2]
Gene ontology Molecular function • potassium:chloride symporter activity • transporter activity • cation:chloride symporter activity Cellular component • extracellular exosome • cell membrane • membrane • integral component of membrane Biological process • ion transport • transmembrane transport • potassium ion transmembrane transport • chloride transmembrane transport • chloride transport • transport • cell volume homeostasis • chloride ion homeostasis • potassium ion homeostasis • potassium ion import across plasma membrane Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56996	83704
Ensembl	ENSG00000146828	ENSMUSG00000037344
UniProt	Q9BXP2	Q99MR3
RefSeq (mRNA)	NM_001267812 NM_001267814 NM_020246 NM_001363493 NM_001363494	NM_031406 NM_001359611
RefSeq (protein)	NP_001254741 NP_001254743 NP_064631 NP_001350422 NP_001350423	NP_113583 NP_001346540
Location (UCSC)	Chr 7: 100.83 – 100.87 Mb	Chr 5: 137.31 – 137.33 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000146828 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037344 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: solute carrier family 12 (potassium/chloride transporters)".
6. Caron L; Rousseau F; Gagnon E; Isenring P (October 2000). "Cloning and functional characterization of a cation-Cl⁻ cotransporter-interacting protein". J. Biol. Chem. 275 (41): 32027–36. doi:10.1074/jbc.M000108200. PMID 10871601.
7. Wilson MD; Riemer C; Martindale DW; Schnupf P; Boright AP; Cheung TL; Hardy DM; Schwartz S; Scherer SW; Tsui LC; Miller W; Koop BF (March 2001). "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5". Nucleic Acids Res. 29 (6): 1352–65. doi:10.1093/nar/29.6.1352. PMC 29746. PMID 11239002.

Further reading

• Eijgelsheim M, Newton-Cheh C, Sotoodehnia N, et al. (2010). "Genome-wide association analysis identifies multiple loci related to resting heart rate". Hum. Mol. Genet. 19 (19): 3885–94. doi:10.1093/hmg/ddq303. PMC 3657480. PMID 20639392.
• de Vries, H; Rüegsegger, U; Hübner, W; Friedlein, A; Langen, H; Keller, W (2000). "Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors". EMBO J. 19 (21): 5895–904. doi:10.1093/emboj/19.21.5895. PMC 305781. PMID 11060040.