SNX21

Sorting nexin-21 is a protein that in humans is encoded by the SNX21 gene.[5][6][7]

SNX21
Identifiers
Aliases	SNX21, C20orf161, PP3993, SNX-L, dJ337O18.4, sorting nexin family member 21
External IDs	MGI: 1917729 HomoloGene: 43132 GeneCards: SNX21
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 45,833,799 bp[1] End 45,843,276 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H3 Start 164,785,823 bp[2] End 164,793,816 bp[2]
Gene ontology Molecular function • lipid binding • phosphatidylinositol binding • phosphatidylinositol-4,5-bisphosphate binding • phosphatidylinositol-3-phosphate binding Cellular component • membrane • cytoplasmic vesicle • cytoplasmic vesicle membrane • endosome • early endosome membrane Biological process • protein transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	90203	101113
Ensembl	ENSG00000124104	ENSMUSG00000050373
UniProt	Q969T3	Q3UR97
RefSeq (mRNA)	NM_001042632 NM_001042633 NM_033421 NM_152897	NM_133924
RefSeq (protein)	NP_001036097 NP_001036098 NP_219489 NP_690857	NP_598685
Location (UCSC)	Chr 20: 45.83 – 45.84 Mb	Chr 2: 164.79 – 164.79 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. The specific function of this protein has not been determined. Multiple transcript variants encoding distinct isoforms have been identified for this gene.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000124104 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050373 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Worby CA, Dixon JE (Dec 2002). "Sorting out the cellular functions of sorting nexins". Nat Rev Mol Cell Biol. 3 (12): 919–31. doi:10.1038/nrm974. PMID 12461558. S2CID 36361630.
6. Zeng W, Yuan W, Wang Y, Jiao W, Zhu Y, Huang C, Li D, Li Y, Zhu C, Wu X, Liu M (Dec 2002). "Expression of a novel member of sorting nexin gene family, SNX-L, in human liver development". Biochem Biophys Res Commun. 299 (4): 542–8. doi:10.1016/S0006-291X(02)02695-5. PMID 12459172.
7. "Entrez Gene: SNX21 sorting nexin family member 21".

Further reading

• Xu Y, Seet LF, Hanson B, Hong W (2002). "The Phox homology (PX) domain, a new player in phosphoinositide signalling". Biochem. J. 360 (Pt 3): 513–30. doi:10.1042/0264-6021:3600513. PMC 1222253. PMID 11736640.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Teasdale RD, Loci D, Houghton F, et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem. J. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546.