SPRED3

Sprouty-related, EVH1 domain-containing protein 3 also known as Spread-3 is a protein that in humans is encoded by the SPRED3 gene.[5]

SPRED3
Identifiers
Aliases	SPRED3, Eve-3, spred-3, sprouty related EVH1 domain containing 3
External IDs	OMIM: 609293 MGI: 2142186 HomoloGene: 28061 GeneCards: SPRED3
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 38,388,421 bp[1] End 38,399,587 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B1 Start 29,158,829 bp[2] End 29,170,411 bp[2]
Gene ontology Molecular function • protein kinase binding Cellular component • membrane Biological process • multicellular organism development • regulation of signal transduction • inactivation of MAPK activity • negative regulation of peptidyl-threonine phosphorylation • positive regulation of DNA damage response, signal transduction by p53 class mediator • regulation of protein deacetylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	399473	101809
Ensembl	ENSG00000188766	ENSMUSG00000037239
UniProt	Q2MJR0	Q6P6N5
RefSeq (mRNA)	NM_001039616 NM_001042522	NM_182927
RefSeq (protein)	NP_001035987	NP_891557
Location (UCSC)	Chr 19: 38.39 – 38.4 Mb	Chr 7: 29.16 – 29.17 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Spread-3 is a member of the Sprouty (see SPRY1/SPRED) family of proteins that regulate growth factor-induced activation of the MAP kinase cascade.[5][6]

References

1. GRCh38: Ensembl release 89: ENSG00000188766 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037239 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: sprouty-related".
6. Nonami A, Kato R, Taniguchi K, Yoshiga D, Taketomi T, Fukuyama S, Harada M, Sasaki A, Yoshimura A (December 2004). "Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells". The Journal of Biological Chemistry. 279 (50): 52543–51. doi:10.1074/jbc.M405189200. PMID 15465815.

Further reading

• Kato R, Nonami A, Taketomi T, Wakioka T, Kuroiwa A, Matsuda Y, Yoshimura A (March 2003). "Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation". Biochemical and Biophysical Research Communications. 302 (4): 767–72. doi:10.1016/S0006-291X(03)00259-6. PMID 12646235.
• Mizoguchi M, Nutt CL, Louis DN (February 2004). "Mutation analysis of CBL-C and SPRED3 on 19q in human glioblastoma". Neurogenetics. 5 (1): 81–2. doi:10.1007/s10048-003-0164-x. PMID 14618415. S2CID 35025882.
• King JA, Corcoran NM, D'Abaco GM, Straffon AF, Smith CT, Poon CL, Buchert M, I S, Hall NE, Lock P, Hovens CM (April 2006). "Eve-3: a liver enriched suppressor of Ras/MAPK signaling". Journal of Hepatology. 44 (4): 758–67. doi:10.1016/j.jhep.2005.10.031. PMID 16478641.
• Lock P, I ST, Straffon AF, Schieb H, Hovens CM, Stylli SS (December 2006). "Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination". Biochemical and Biophysical Research Communications. 351 (4): 1018–23. doi:10.1016/j.bbrc.2006.10.150. PMID 17094949.