Small nucleolar RNA SNORA43
Small nucleolar RNA SNORA43 (also known as ACA43) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'.
| Small nucleolar RNA SNORA43 | |
|---|---|
 Predicted secondary structure and sequence conservation of SNORA43 | |
| Identifiers | |
| Symbol | SNORA43 |
| Alt. Symbols | snoACA43 |
| Rfam | RF00416 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; HACA-box |
| Domain(s) | Eukaryota |
| GO | GO:0006396 GO:0005730 |
| SO | SO:0000594 |
| PDB structures | PDBe |
ACA43 was originally cloned from HeLa cells[1] and belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure, has the conserved H/ACA-box motifs and is found associated with GAR1 protein. snoRNA ACA43 is predicted to guide the pseudouridylation of U4938 of 28S ribosomal RNA (rRNA). Pseudouridylation is the isomerisation of the nucleoside uridine to the different isomeric form pseudouridine.
References
- Kiss AM, Jády BE, Bertrand E, Kiss T (July 2004). "Human box H/ACA pseudouridylation guide RNA machinery". Molecular and Cellular Biology. 24 (13): 5797–807. doi:10.1128/MCB.24.13.5797-5807.2004. PMC 480876. PMID 15199136.