Startle response

In animals, including humans, the startle response is a largely unconscious defensive response to sudden or threatening stimuli, such as sudden noise or sharp movement, and is associated with negative affect.[1] Usually the onset of the startle response is a startle reflex reaction. The startle reflex is a brainstem reflectory reaction (reflex) that serves to protect vulnerable parts, such as the back of the neck (whole-body startle) and the eyes (eyeblink) and facilitates escape from sudden stimuli. It is found across the lifespan of many species. A variety of responses may occur because of individual's emotional state,[2] body posture,[3] preparation for execution of a motor task,[4] or other activities.[5] The startle response is implicated in the formation of specific phobias.

"Startle" redirects here. For other uses, see Startle (disambiguation).

Startle reflex

Neurophysiology
Layout of the brain

A startle reflex can occur in the body through a combination of actions. A reflex from hearing a sudden loud noise will happen in the primary acoustic startle reflex pathway consisting of three main central synapses, or signals that travel through the brain.

First, there is a synapse from the auditory nerve fibers in the ear to the cochlear root neurons (CRN). These are the first acoustic neurons of the central nervous system. Studies have shown a direct correlation to the amount of decrease of the startle to the number of CRNs that were killed. Second, there is a synapse from the CRN axons to the cells in the nucleus reticularis pontis caudalis (PnC) of the brain. These are neurons that are located in the pons of the brainstem. A study done to disrupt this portion of the pathway by the injection of PnC inhibitory chemicals has shown a dramatic decrease in the amount of startle by about 80 to 90 percent. Third, a synapse occurs from the PnC axons to the motor neurons in the facial motor nucleus or the spinal cord that will directly or indirectly control the movement of muscles. The activation of the facial motor nucleus causes a jerk of the head while an activation in the spinal cord causes the whole body to startle.[6]

During neuromotor examinations of newborns, it is noted that, for a number of techniques, the patterns of the startle reaction and the Moro reflex may significantly overlap, the notable distinction being the absence of arm abduction (spreading) during startle responses.[7]

Reflexes

There are many various reflexes that can occur simultaneously during a startle response. The fastest reflex recorded in humans happens within the masseter muscle or jaw muscle. The reflex was measured by electromyography which records the electrical activity during movement of the muscles. This also showed the latency response or the delay between the stimulus and the response recorded was found to be about 14 milliseconds. The blink of the eye which is the reflex of the orbicularis oculi muscle was found to have a latency of about 20 to 40 milliseconds. Out of larger body parts, the head is quickest in a movement latency in a range from 60 to 120 milliseconds. The neck then moves almost simultaneously with a latency of 75 to 121 milliseconds. Next, the shoulder jerks at 100 to 121 milliseconds along with the arms at 125 to 195 milliseconds. Lastly the legs responds with a latency of 145 to 395 milliseconds. This type of cascading response correlates to how the synapses travel from the brain and down the spinal cord to activate each motor neuron.[8]

Acoustic startle reflex

The acoustic startle reflex is thought to be caused by an auditory stimulus greater than 80 decibels.[1] The reflex is typically measured by electromyography, brain imaging or sometimes positron electron tomography.[9][10] There are many brain structures and pathways thought to be involved in the reflex. The amygdala, hippocampus, bed nucleus of the stria terminalis (BNST) and anterior cingulate cortex are all thought to play a role in modulating the reflex.[11][12] The anterior cingulate cortex in the brain is largely thought to be the main area associated with emotional response and awareness, which can contribute to the way an individual reacts to startle-inducing stimuli.[11] Along with the anterior cingulate cortex, the amygdala and the hippocampus are known to have implications in this reflex.

The amygdala is known to have a role in the "fight-or-flight response", and the hippocampus functions to form memories of the stimulus and the emotions associated with it.[13] The role of the BNST in the acoustic startle reflex may be attributed to specific areas within the nucleus responsible for stress and anxiety responses.[12] Activation of the BNST by certain hormones is thought to promote a startle response[12] The auditory pathway for this response was largely elucidated in rats in the 1980s.[14] The basic pathway follows the auditory pathway from the ear up to the nucleus of the lateral lemniscus (LLN) from where it activates a motor centre in the reticular formation. This centre sends descending projections to lower motor neurones of the limbs.

In slightly more detail this corresponds to ear (cochlea) → cranial nerve VIII (auditory) → cochlear nucleus (ventral/inferior) → LLN → caudal pontine reticular nucleus (PnC). The whole process has a less than 10ms latency. There is no involvement of the superior/rostral or inferior/caudal colliculus in the reaction that "twitches" the hindlimbs, but these may be important for adjustment of pinnae and gaze towards the direction of the sound, or for the associated blink.[15]

Application in occupational settings

In a 2005 study by Martin et al., at the Department of Aviation and Logistics, University of Southern Queensland, the performance of aircraft pilots following unexpected critical events, in relation to recent aircraft accidents, is examined. The deleterious effects of the startle response was identified as causal or contributory in these events. The authors argue that fear resulting from threat (especially if life-threatening[16][17]) potentiates startle effects and has significant deleterious effects on cognition. This could contribute to poor performance following an unexpected critical event in aviation. They discuss training strategies for improved performance, which would expose pilots to unexpected critical events more often, and develop greater self-efficacy.[18]

See also

References
  1. Rammirez-Moreno, David. "A computational model for the modulation of the prepulse inhibition of the acoustic startle reflex". Biological Cybernetics, 2012, p. 169
  2. Lang, Peter J.; Bradley, Margaret M.; Cuthbert, Bruce N. (1990). "Emotion, attention, and the startle reflex". Psychological Review. 97 (3): 377–95. doi:10.1037/0033-295X.97.3.377. ISSN 1939-1471. PMID 2200076.
  3. Castellote et al (2007) cited Brown, P; Day, BL; Rothwell, JC; Thompson, PD; Marsden, CD (1991b). "The effect of posture on the normal and pathological auditory startle reflex". J Neurol Neurosurg Psychiatry. 54 (10): 892–97. doi:10.1136/jnnp.54.10.892. PMC 1014574. PMID 1744643.
  4. Castellote et al (2007) cited Valls-Sole, J; Rothwell, JC; Goulart, F; Cossu, G; Munoz, E (1999). "Patterned ballistic movements triggered by a startle in healthy humans". J Physiol. 516 (3): 931–38. doi:10.1111/j.1469-7793.1999.0931u.x. PMC 2269293. PMID 10200438.
  5. Castellote et al (2007) cited Nieuwenhuijzen, PH; Schillings, AM; Van Galen, GP; Duysens, J (2000). "Modulation of the startle response during human gait". J Neurophysiol. 84 (1): 65–74. doi:10.1152/jn.2000.84.1.65. PMID 10899184.
  6. Davis, M. (2007). "Neural systems involved in fear and anxiety based on the fear-potentiated startle test." Neurobiology of Learning and Memory (pp. 381–425). Elsevier Incorporated.
  7. Fletcher, Mary Ann (1998). Physical Diagnosis in Neonatology. p. 472. ISBN 978-0397513864.
  8. Davis, M. (1984). "The mammalian startle response". In R. Eaton (Ed.), Neural stop of Startle Behavior (pp. 287–351). Plenum Publishing Corporation.
  9. Pissiota, Anna. "Amygdala and Anterior Cingulate Cortex Activation During Affective Startle Modulation:a PET Study of Fear". The European Journal of Neuroscience, 2003, p. 1325
  10. Phillips, R.G. "Differential Contribution of Amygdala and Hippocampus to Cued and Contextual Fear Conditioning". Behavioral Neuroscience, 1992, p. 274
  11. Medford, Nick. "Conjoint Activity of Anterior Insular and Anterior Cingulate Cortex:Awareness and Response". Brain Structure and Function, 2010, p. 535
  12. Lee, Younglim. "Role of the Hippocampus, the Bed Nucleus of the Stria Terminalis, and the Amygdala in the Excitatory Effect of Corticotropin-Releasing Hormone on the Acoustic Startle Reflex". The Journal of Neuroscience, 1997, p. 6434
  13. Grouen, Wouter. "Amygdala and Hippocampus Enlargement During Adolescence in Autism". Journal of the American Academy of Child & Adolescent Psychiatry, 2010, p. 552
  14. Davis, M; Gendelman, Ds; Tischler, Md; Gendelman, Pm (Jun 1982). "A primary acoustic startle circuit: lesion and stimulation studies". Journal of Neuroscience. 2 (6): 791–805. doi:10.1523/JNEUROSCI.02-06-00791.1982. ISSN 0270-6474. PMC 6564345. PMID 7086484.
  15. Castellote, Jm; Kumru, H; Queralt, A; Valls-Solé, J (Feb 2007). "A startle speeds up the execution of externally guided saccades". Experimental Brain Research. Experimentelle Hirnforschung. Experimentation Cerebrale. 177 (1): 129–36. doi:10.1007/s00221-006-0659-4. ISSN 0014-4819. PMID 16944110. S2CID 19678962.
  16. Martin, Wayne; Murray, Patrick; Bates, Paul (2012). The Effects of Startle on Pilots During Critical Events: A Case Study Analysis (PDF). 30th EAAP Conference : Aviation Psychology & Applied Human Factors – working towards zero accidents. Discussion, p. 389. Archived (PDF) from the original on 2019-09-16. Retrieved 2019-09-12.
  17. Field, JN; Boland, EJ; van Rooij, JM; Mohrmann, JFW; Smeltink, JW. Startle Effect Management (Report Number NLR-CR-2018-242) (PDF) (Report). European Aviation Safety Agency. 2.4.3 Fear-potentiated Startle or Surprise, p. 18. Retrieved 2019-09-12. cited Martin, W; Murray, P (2013). Training Interventions for Managing Startle During Unexpected Critical Events. 66th International Air Safety Summit. Flight Safety Foundation.
  18. Martin, Wayne L.; Murray, Patrick S.; Bates, Paul R.; Lee, Paul S. Y. (2015). "Fear-Potentiated Startle: A Review from an Aviation Perspective". The International Journal of Aviation Psychology. 25 (2): 97–107. doi:10.1080/10508414.2015.1128293. S2CID 147250211.
  • Carney Landis; William Alvin Hunt; Hans Strauss (1939). The startle pattern. Farrar & Rinehart., review
  • Robert C. Eaton (1984). Neural Mechanisms of Startle Behavior. ISBN 978-0306415562.
  • Jones, FP; Hanson, JA; Gray, FE (1964). "Startle as a Paradigm for Malposture". Perceptual and Motor Skills. 19: 21–22. doi:10.2466/pms.1964.19.1.21. PMID 14197451. S2CID 10095410.
  • Jones, FP (1965). "Method for Changing Stereotyped Response Patterns by the Inhibition of Certain Postural Sets". Psychological Review. 72 (3): 196–214. doi:10.1037/h0021752. PMID 14324557.
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