TNRC6B

Trinucleotide repeat-containing gene 6B protein is a protein that in humans is encoded by the TNRC6B gene.[5]

TNRC6B
Identifiers
Aliases	TNRC6B, trinucleotide repeat containing 6B, trinucleotide repeat containing adaptor 6B
External IDs	OMIM: 610740 MGI: 2443730 HomoloGene: 66194 GeneCards: TNRC6B
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 40,044,817 bp[1] End 40,335,808 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 80,711,313 bp[2] End 80,941,085 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • nucleic acid binding • RNA binding Cellular component • cytoplasm • cytosol • P-body • nucleoplasm Biological process • posttranscriptional gene silencing by RNA • positive regulation of nuclear-transcribed mRNA poly(A) tail shortening • regulation of translation • positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • gene silencing by RNA • miRNA mediated inhibition of translation • Wnt signaling pathway, calcium modulating pathway • regulation of megakaryocyte differentiation • positive regulation of gene expression • negative regulation of gene expression • gene silencing by miRNA Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23112	213988
Ensembl	ENSG00000100354	ENSMUSG00000047888
UniProt	Q9UPQ9	Q8BKI2
RefSeq (mRNA)	NM_015088 NM_001024843 NM_001162501	NM_144812 NM_177124
RefSeq (protein)	NP_001020014 NP_001155973 NP_055903	NP_659061 NP_796098
Location (UCSC)	Chr 22: 40.04 – 40.34 Mb	Chr 15: 80.71 – 80.94 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TNRC6B has been shown to interact with EIF2C2.[6] It is also known to associate with argonaute proteins and has been shown to be required for miRNA-guided gene silencing in HeLa cells.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000100354 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047888 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: TNRC6B trinucleotide repeat containing 6B".
6. Till S, Lejeune E, Thermann R, Bortfeld M, Hothorn M, Enderle D, Heinrich C, Hentze MW, Ladurner AG (October 2007). "A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain". Nat. Struct. Mol. Biol. 14 (10): 897–903. doi:10.1038/nsmb1302. PMID 17891150.
7. Meister G, Landthaler M, Peters L, Chen PY, Urlaub H, Lührmann R, Tuschl T (December 2005). "Identification of novel argonaute-associated proteins". Curr. Biol. 15 (23): 2149–55. doi:10.1016/j.cub.2005.10.048. hdl:11858/00-001M-0000-0012-E763-B. PMID 16289642.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Gubin AN, Njoroge JM, Bouffard GG, Miller JL (1999). "Gene expression in proliferating human erythroid cells" (PDF). Genomics. 59 (2): 168–77. doi:10.1006/geno.1999.5855. PMID 10409428.
• Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Schneider MD, Najand N, Chaker S, et al. (2006). "Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development". J. Cell Biol. 174 (3): 349–58. doi:10.1083/jcb.200512103. PMC 2064231. PMID 16880270.