TRAF5

TNF receptor-associated factor 5 is a protein that in humans is encoded by the TRAF5 gene.[4]

TRAF5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4GJH
Identifiers
Aliases	TRAF5, MGC:39780, RNF84, TNF receptor associated factor 5
External IDs	OMIM: 602356 MGI: 107548 HomoloGene: 27079 GeneCards: TRAF5
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.3 Start 211,326,615 bp[1] End 211,374,946 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • thioesterase binding • zinc ion binding • GO:0001948 protein binding • ubiquitin protein ligase binding • metal ion binding • identical protein binding • tumor necrosis factor receptor binding Cellular component • cytosol • cytoplasmic side of plasma membrane • centrosome • CD40 receptor complex • cytoplasm • macromolecular complex Biological process • regulation of apoptotic process • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of NF-kappaB transcription factor activity • signal transduction • apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7188	22033
Ensembl	ENSG00000082512	ENSMUSG00000026637
UniProt	O00463	P70191
RefSeq (mRNA)	NM_001033910 NM_004619 NM_145759 NM_001319207	NM_011633
RefSeq (protein)	NP_001029082 NP_001306136 NP_004610 NP_665702	NP_035763
Location (UCSC)	Chr 1: 211.33 – 211.37 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Function

The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Alternate transcriptional splice variants have been characterized.[5]

Interactions

TRAF5 has been shown to interact with:

• ASK1,[6][7]
• CD134,[8]
• CD30,[9]
• CD40,[10][11]
• RANK[12][13][14]
• TNFRSF13B,[15] and
• TNFRSF14.[16][17]

References

1. GRCh38: Ensembl release 89: ENSG00000082512 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Tang XX, Pleasure DE, Ikegaki N (Apr 1997). "cDNA cloning, chromosomal localization, and expression pattern of EPLG8, a new member of the EPLG gene family encoding ligands of EPH-related protein-tyrosine kinase receptors". Genomics. 41 (1): 17–24. doi:10.1006/geno.1997.4615. PMID 9126477.
5. "Entrez Gene: TRAF5 TNF receptor-associated factor 5".
6. Nishitoh H, Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H (Sep 1998). "ASK1 is essential for JNK/SAPK activation by TRAF2". Molecular Cell. 2 (3): 389–95. doi:10.1016/s1097-2765(00)80283-x. PMID 9774977.
7. Hoeflich KP, Yeh WC, Yao Z, Mak TW, Woodgett JR (Oct 1999). "Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)". Oncogene. 18 (42): 5814–20. doi:10.1038/sj.onc.1202975. PMID 10523862.
8. Kawamata S, Hori T, Imura A, Takaori-Kondo A, Uchiyama T (Mar 1998). "Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation". The Journal of Biological Chemistry. 273 (10): 5808–14. doi:10.1074/jbc.273.10.5808. PMID 9488716.
9. Aizawa S, Nakano H, Ishida T, Horie R, Nagai M, Ito K, Yagita H, Okumura K, Inoue J, Watanabe T (Jan 1997). "Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation". The Journal of Biological Chemistry. 272 (4): 2042–5. doi:10.1074/jbc.272.4.2042. PMID 8999898.
10. Tsukamoto N, Kobayashi N, Azuma S, Yamamoto T, Inoue J (Feb 1999). "Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40". Proceedings of the National Academy of Sciences of the United States of America. 96 (4): 1234–9. doi:10.1073/pnas.96.4.1234. PMC 15446. PMID 9990007.
11. Ishida TK, Tojo T, Aoki T, Kobayashi N, Ohishi T, Watanabe T, Yamamoto T, Inoue J (Sep 1996). "TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling". Proceedings of the National Academy of Sciences of the United States of America. 93 (18): 9437–42. doi:10.1073/pnas.93.18.9437. PMC 38446. PMID 8790348.
12. Darnay BG, Haridas V, Ni J, Moore PA, Aggarwal BB (Aug 1998). "Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase". The Journal of Biological Chemistry. 273 (32): 20551–5. doi:10.1074/jbc.273.32.20551. PMID 9685412.
13. Darnay BG, Ni J, Moore PA, Aggarwal BB (Mar 1999). "Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif". The Journal of Biological Chemistry. 274 (12): 7724–31. doi:10.1074/jbc.274.12.7724. PMID 10075662.
14. Galibert L, Tometsko ME, Anderson DM, Cosman D, Dougall WC (Dec 1998). "The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily". The Journal of Biological Chemistry. 273 (51): 34120–7. doi:10.1074/jbc.273.51.34120. PMID 9852070.
15. Xia XZ, Treanor J, Senaldi G, Khare SD, Boone T, Kelley M, Theill LE, Colombero A, Solovyev I, Lee F, McCabe S, Elliott R, Miner K, Hawkins N, Guo J, Stolina M, Yu G, Wang J, Delaney J, Meng SY, Boyle WJ, Hsu H (Jul 2000). "TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation". The Journal of Experimental Medicine. 192 (1): 137–43. doi:10.1084/jem.192.1.137. PMC 1887716. PMID 10880535.
16. Hsu H, Solovyev I, Colombero A, Elliott R, Kelley M, Boyle WJ (May 1997). "ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5". The Journal of Biological Chemistry. 272 (21): 13471–4. doi:10.1074/jbc.272.21.13471. PMID 9153189.
17. Marsters SA, Ayres TM, Skubatch M, Gray CL, Rothe M, Ashkenazi A (May 1997). "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1". The Journal of Biological Chemistry. 272 (22): 14029–32. doi:10.1074/jbc.272.22.14029. PMID 9162022.

Further reading

• Wajant H, Henkler F, Scheurich P (Jun 2001). "The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators". Cellular Signalling. 13 (6): 389–400. doi:10.1016/S0898-6568(01)00160-7. PMID 11384837.
• Bradley JR, Pober JS (Oct 2001). "Tumor necrosis factor receptor-associated factors (TRAFs)". Oncogene. 20 (44): 6482–91. doi:10.1038/sj.onc.1204788. PMID 11607847.
• Nakano H, Oshima H, Chung W, Williams-Abbott L, Ware CF, Yagita H, Okumura K (Jun 1996). "TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor". The Journal of Biological Chemistry. 271 (25): 14661–4. doi:10.1074/jbc.271.25.14661. PMID 8663299.
• Ishida TK, Tojo T, Aoki T, Kobayashi N, Ohishi T, Watanabe T, Yamamoto T, Inoue J (Sep 1996). "TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling". Proceedings of the National Academy of Sciences of the United States of America. 93 (18): 9437–42. doi:10.1073/pnas.93.18.9437. PMC 38446. PMID 8790348.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Aizawa S, Nakano H, Ishida T, Horie R, Nagai M, Ito K, Yagita H, Okumura K, Inoue J, Watanabe T (Jan 1997). "Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation". The Journal of Biological Chemistry. 272 (4): 2042–5. doi:10.1074/jbc.272.4.2042. PMID 8999898.
• Hsu H, Solovyev I, Colombero A, Elliott R, Kelley M, Boyle WJ (May 1997). "ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5". The Journal of Biological Chemistry. 272 (21): 13471–4. doi:10.1074/jbc.272.21.13471. PMID 9153189.
• Marsters SA, Ayres TM, Skubatch M, Gray CL, Rothe M, Ashkenazi A (May 1997). "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1". The Journal of Biological Chemistry. 272 (22): 14029–32. doi:10.1074/jbc.272.22.14029. PMID 9162022.
• Nakano H, Shindo M, Yamada K, Yoshida MC, Santee SM, Ware CF, Jenkins NA, Gilbert DJ, Yagita H, Copeland NC, Okumura K (May 1997). "Human TNF receptor-associated factor 5 (TRAF5): cDNA cloning, expression and assignment of the TRAF5 gene to chromosome 1q32". Genomics. 42 (1): 26–32. doi:10.1006/geno.1997.4697. PMID 9177772.
• Song HY, Régnier CH, Kirschning CJ, Goeddel DV, Rothe M (Sep 1997). "Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2". Proceedings of the National Academy of Sciences of the United States of America. 94 (18): 9792–6. doi:10.1073/pnas.94.18.9792. PMC 23270. PMID 9275204.
• Kawamata S, Hori T, Imura A, Takaori-Kondo A, Uchiyama T (Mar 1998). "Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation". The Journal of Biological Chemistry. 273 (10): 5808–14. doi:10.1074/jbc.273.10.5808. PMID 9488716.
• Mizushima S, Fujita M, Ishida T, Azuma S, Kato K, Hirai M, Otsuka M, Yamamoto T, Inoue J (Jan 1998). "Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5)". Gene. 207 (2): 135–40. doi:10.1016/S0378-1119(97)00616-1. PMID 9511754.
• Akiba H, Nakano H, Nishinaka S, Shindo M, Kobata T, Atsuta M, Morimoto C, Ware CF, Malinin NL, Wallach D, Yagita H, Okumura K (May 1998). "CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase". The Journal of Biological Chemistry. 273 (21): 13353–8. doi:10.1074/jbc.273.21.13353. PMID 9582383.
• McCarthy JV, Ni J, Dixit VM (Jul 1998). "RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase". The Journal of Biological Chemistry. 273 (27): 16968–75. doi:10.1074/jbc.273.27.16968. PMID 9642260.
• Pullen SS, Miller HG, Everdeen DS, Dang TT, Crute JJ, Kehry MR (Aug 1998). "CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization". Biochemistry. 37 (34): 11836–45. doi:10.1021/bi981067q. PMID 9718306.
• Wong BR, Josien R, Lee SY, Vologodskaia M, Steinman RM, Choi Y (Oct 1998). "The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor". The Journal of Biological Chemistry. 273 (43): 28355–9. doi:10.1074/jbc.273.43.28355. PMID 9774460.
• Nishitoh H, Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H (Sep 1998). "ASK1 is essential for JNK/SAPK activation by TRAF2". Molecular Cell. 2 (3): 389–95. doi:10.1016/S1097-2765(00)80283-X. PMID 9774977.
• Tsukamoto N, Kobayashi N, Azuma S, Yamamoto T, Inoue J (Feb 1999). "Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40". Proceedings of the National Academy of Sciences of the United States of America. 96 (4): 1234–9. doi:10.1073/pnas.96.4.1234. PMC 15446. PMID 9990007.