TSEN15

tRNA-splicing endonuclease subunit Sen15 is an enzyme that in humans is encoded by the TSEN15 gene.[5][6][7]

TSEN15
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GW6
Identifiers
Aliases	TSEN15, C1orf19, sen15, tRNA splicing endonuclease subunit 15, PCH2F
External IDs	OMIM: 608756 MGI: 1913887 HomoloGene: 12002 GeneCards: TSEN15
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.3 Start 184,051,651 bp[1] End 184,123,978 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 G2 Start 152,370,735 bp[2] End 152,386,688 bp[2]
Gene ontology Molecular function • tRNA-intron endonuclease activity • nucleic acid binding • nuclease activity Cellular component • nucleolus • cell nucleus • nucleoplasm Biological process • mRNA processing • RNA phosphodiester bond hydrolysis • RNA phosphodiester bond hydrolysis, endonucleolytic • tRNA processing • tRNA splicing, via endonucleolytic cleavage and ligation • nucleic acid phosphodiester bond hydrolysis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	116461	66637
Ensembl	ENSG00000198860	ENSMUSG00000014980
UniProt	Q8WW01	Q8R3W5
RefSeq (mRNA)	NM_001127394 NM_001300764 NM_001300766 NM_052965 NM_001363643	NM_025677
RefSeq (protein)	NP_001120866 NP_001287693 NP_001287695 NP_443197 NP_001350572	NP_079953
Location (UCSC)	Chr 1: 184.05 – 184.12 Mb	Chr 1: 152.37 – 152.39 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

tRNA splicing is a fundamental process for cell growth and division. SEN15 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM][7]

Interactions

C1orf19 has been shown to interact with TSEN2.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000198860 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000014980 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sood R, Bonner TI, Makalowska I, Stephan DA, Robbins CM, Connors TD, et al. (April 2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics. 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611.
6. Song J, Markley JL (February 2007). "Three-dimensional structure determined for a subunit of human tRNA splicing endonuclease (Sen15) reveals a novel dimeric fold". Journal of Molecular Biology. 366 (1): 155–64. doi:10.1016/j.jmb.2006.11.024. PMC 1865571. PMID 17166513.
7. "Entrez Gene: C1orf19 chromosome 1 open reading frame 19".
8. Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR (April 2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell. 117 (3): 311–21. doi:10.1016/S0092-8674(04)00342-3. PMID 15109492. S2CID 16049289.

Further reading

• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, et al. (July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Lehner B, Sanderson CM (July 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR (April 2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell. 117 (3): 311–21. doi:10.1016/S0092-8674(04)00342-3. PMID 15109492. S2CID 16049289.