TSEN2

tRNA-splicing endonuclease subunit Sen2 is an enzyme that in humans is encoded by the TSEN2 gene.[5][6]

TSEN2
Identifiers
Aliases	TSEN2, PCH2B, SEN2, SEN2L, tRNA splicing endonuclease subunit 2
External IDs	OMIM: 608753 MGI: 2141599 HomoloGene: 41622 GeneCards: TSEN2
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p25.2 Start 12,484,432 bp[1] End 12,539,623 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 E3 Start 115,544,664 bp[2] End 115,578,628 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • tRNA-intron endonuclease activity • GO:0001948 protein binding • lyase activity • nucleic acid binding • nuclease activity Cellular component • centrosome • nucleolus • cell nucleus • tRNA-intron endonuclease complex • nucleoplasm • cytosol Biological process • mRNA processing • tRNA-type intron splice site recognition and cleavage • RNA phosphodiester bond hydrolysis, endonucleolytic • tRNA splicing, via endonucleolytic cleavage and ligation • RNA phosphodiester bond hydrolysis • tRNA processing • nucleic acid phosphodiester bond hydrolysis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80746	381802
Ensembl	ENSG00000154743	ENSMUSG00000042389
UniProt	Q8NCE0	Q6P7W5
RefSeq (mRNA)	NM_001145392 NM_001145393 NM_001145394 NM_001145395 NM_025265 NM_001321277 NM_001321278 NM_001321279	NM_199033
RefSeq (protein)	NP_001138864 NP_001138865 NP_001138866 NP_001308206 NP_001308207 NP_001308208 NP_079541	NP_950198
Location (UCSC)	Chr 3: 12.48 – 12.54 Mb	Chr 6: 115.54 – 115.58 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

tRNA splicing is a fundamental process required for cell growth and division. SEN2 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM][6]

Interactions

TSEN2 has been shown to interact with TSEN34[5] and C1orf19.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000154743 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042389 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR (Apr 2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell. 117 (3): 311–21. doi:10.1016/S0092-8674(04)00342-3. PMID 15109492. S2CID 16049289.
6. "Entrez Gene: TSEN2 tRNA splicing endonuclease 2 homolog (S. cerevisiae)".

External links

• GeneReviews/NCBI/NIH/UW entry on Pontocerebellar Hypoplasia Type 2 and Type 4

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.