TSEN34

tRNA-splicing endonuclease subunit Sen34 is an enzyme that in humans is encoded by the TSEN34 gene.[5][6][7]

TSEN34
Identifiers
Aliases	TSEN34, LENG5, PCH2C, SEN34, SEN34L, tRNA splicing endonuclease subunit 34
External IDs	OMIM: 608754 MGI: 1913328 HomoloGene: 44182 GeneCards: TSEN34
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 54,189,938 bp[1] End 54,194,536 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A1 Start 3,692,863 bp[2] End 3,701,024 bp[2]
Gene ontology Molecular function • tRNA-intron endonuclease activity • lyase activity • nucleic acid binding • nuclease activity Cellular component • nucleolus • cell nucleus • tRNA-intron endonuclease complex • nucleoplasm Biological process • mRNA processing • tRNA-type intron splice site recognition and cleavage • RNA phosphodiester bond hydrolysis, endonucleolytic • tRNA splicing, via endonucleolytic cleavage and ligation • RNA phosphodiester bond hydrolysis • tRNA processing • nucleic acid phosphodiester bond hydrolysis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79042	66078
Ensembl	ENSG00000278622 ENSG00000274129 ENSG00000274796 ENSG00000278712 ENSG00000275165 ENSG00000278605 ENSG00000273896 ENSG00000274078 ENSG00000274672 ENSG00000170892	ENSMUSG00000035585
UniProt	Q9BSV6	Q8BMZ5
RefSeq (mRNA)	NM_001077446 NM_001282332 NM_001282333 NM_024075	NM_001164204 NM_001164205 NM_024168
RefSeq (protein)	NP_001070914 NP_001269261 NP_001269262 NP_076980	NP_001157676 NP_001157677 NP_077130
Location (UCSC)	Chr 19: 54.19 – 54.19 Mb	Chr 7: 3.69 – 3.7 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

tRNA splicing is a fundamental process required for cell growth and division. SEN34 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM][7]

Interactions

TSEN34 has been shown to interact with TSEN2.[6]

References

1. ENSG00000274129, ENSG00000274796, ENSG00000278712, ENSG00000275165, ENSG00000278605, ENSG00000273896, ENSG00000274078, ENSG00000274672, ENSG00000170892 GRCh38: Ensembl release 89: ENSG00000278622, ENSG00000274129, ENSG00000274796, ENSG00000278712, ENSG00000275165, ENSG00000278605, ENSG00000273896, ENSG00000274078, ENSG00000274672, ENSG00000170892 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035585 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wende H, Volz A, Ziegler A (Sep 2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID 10941842. S2CID 20719684.
6. Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR (Apr 2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell. 117 (3): 311–21. doi:10.1016/S0092-8674(04)00342-3. PMID 15109492. S2CID 16049289.
7. "Entrez Gene: TSEN34 tRNA splicing endonuclease 34 homolog (S. cerevisiae)".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

External links

• GeneReviews/NCBI/NIH/UW entry on Pontocerebellar Hypoplasia Type 2 and Type 4