Trequinsin

Trequinsin is a phosphodiesterase inhibitor.[1] It has been shown to improve sperm motility in vitro.[2]

Trequinsin

Names
IUPAC name 9,10-Dimethoxy-3-methyl-2-(2,4,6-trimethylphenyl)imino-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one
Identifiers
3D model (JSmol)	Interactive image
ChemSpider	5336
PubChem CID	5537
CompTox Dashboard (EPA)	DTXSID2048458
InChI InChI=1S/C24H27N3O3/c1-14-9-15(2)23(16(3)10-14)25-22-13-19-18-12-21(30-6)20(29-5)11-17(18)7-8-27(19)24(28)26(22)4/h9-13H,7-8H2,1-6H3 Key: MCMSJVMUSBZUCN-UHFFFAOYSA-N
SMILES CC1=CC(=C(C(=C1)C)N=C2C=C3C4=CC(=C(C=C4CCN3C(=O)N2C)OC)OC)C
Properties
Chemical formula	C24H27N3O3
Molar mass	405.498 g·mol^−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

References

1. Whitaker, RM; Wills, LP; Stallons, LJ; Schnellmann, RG (2013). "CGMP-Selective Phosphodiesterase Inhibitors Stimulate Mitochondrial Biogenesis and Promote Recovery from Acute Kidney Injury". The Journal of Pharmacology and Experimental Therapeutics. 347 (3): 626–34. doi:10.1124/jpet.113.208017. PMC 3836317. PMID 24042162.
2. McBrinn RC, Fraser J, Hope AG, Gray DW, Barratt CLR, Martins da Silva SJ, Brown SG. Novel pharmacological actions of trequinsin hydrochloride improve human sperm cell motility and function. Br J Pharmacol. 2019 Dec;176(23):4521-4536. doi:10.1111/bph.14814 PMID 31368510