Triphosphoribosyl-dephospho-CoA synthase
In enzymology, a triphosphoribosyl-dephospho-CoA synthase (EC 2.7.8.25) is an enzyme that catalyzes the chemical reaction
- ATP + 3-dephospho-CoA 2'-(5"-triphosphoribosyl)-3'-dephospho-CoA + adenine
| triphosphoribosyl-dephospho-CoA synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.7.8.25 | ||||||||
| CAS number | 313345-38-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are ATP and 3-dephospho-CoA, whereas its two products are 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA and adenine.
This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is ATP:3-dephospho-CoA 5"-triphosphoribosyltransferase. Other names in common use include 2'-(5"-triphosphoribosyl)-3-dephospho-CoA synthase, ATP:dephospho-CoA 5-triphosphoribosyl transferase, and CitG. This enzyme participates in two-component system - general.
References
- Schneider K, Dimroth P, Bott M (2000). "Biosynthesis of the prosthetic group of citrate lyase". Biochemistry. 39 (31): 9438–50. doi:10.1021/bi000401r. PMID 10924139.
- Schneider K, Dimroth P, Bott M (2000). "Identification of triphosphoribosyl-dephospho-CoA as precursor of the citrate lyase prosthetic group". FEBS Lett. 483 (2–3): 165–8. doi:10.1016/S0014-5793(00)02105-0. PMID 11042274.
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