XPO4

Exportin-4 is a protein that in humans is encoded by the XPO4 gene.[5][6][7]

XPO4
Identifiers
Aliases	XPO4, exp4, exportin 4
External IDs	OMIM: 611449 MGI: 1888526 HomoloGene: 10733 GeneCards: XPO4
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q12.11 Start 20,777,329 bp[1] End 20,903,048 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C3 Start 57,577,521 bp[2] End 57,665,430 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nuclear export signal receptor activity • GO:0001948 protein binding • Ran GTPase binding Cellular component • nuclear pore • cell nucleus • nucleoplasm • cytoplasm • cytosol Biological process • positive regulation of protein export from nucleus • protein transport • nuclear export • protein export from nucleus Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64328	57258
Ensembl	ENSG00000132953	ENSMUSG00000021952
UniProt	Q9C0E2	Q9ESJ0
RefSeq (mRNA)	NM_022459 NM_001372061	NM_020506
RefSeq (protein)	NP_071904 NP_001358990	NP_065252 NP_001355626 NP_001355627
Location (UCSC)	Chr 13: 20.78 – 20.9 Mb	Chr 14: 57.58 – 57.67 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Chromosome 13 (human)
• Protein transport
• Ran (gene)
• SMAD3

References

1. GRCh38: Ensembl release 89: ENSG00000132953 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021952 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
6. Lipowsky G, Bischoff FR, Schwarzmaier P, Kraft R, Kostka S, Hartmann E, Kutay U, Gorlich D (Sep 2000). "Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes". EMBO J. 19 (16): 4362–71. doi:10.1093/emboj/19.16.4362. PMC 302028. PMID 10944119.
7. "Entrez Gene: XPO4 exportin 4".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Kurisaki A, Kurisaki K, Kowanetz M, et al. (2006). "The Mechanism of Nuclear Export of Smad3 Involves Exportin 4 and Ran". Mol. Cell. Biol. 26 (4): 1318–32. doi:10.1128/MCB.26.4.1318-1332.2006. PMC 1367208. PMID 16449645.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.