ABL2

Tyrosine-protein kinase ABL2 also known as Abelson-related gene (Arg) is an enzyme that in humans is encoded by the ABL2 gene.[5][6]

ABL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ECD, 2KK1, 2XYN, 3GVU, 3HMI, 3ULR, 4EIH
Identifiers
Aliases	ABL2, ABLL, ARG, ABL proto-oncogene 2, non-receptor tyrosine kinase
External IDs	OMIM: 164690 MGI: 87860 HomoloGene: 5278 GeneCards: ABL2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.2 Start 179,099,330 bp[1] End 179,229,684 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 G3|1 67.71 cM Start 156,558,786 bp[2] End 156,649,568 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • actin monomer binding • manganese ion binding • non-membrane spanning protein tyrosine kinase activity • metal ion binding • kinase activity • actin filament binding • GO:0001948 protein binding • receptor binding • ATP binding • magnesium ion binding • protein tyrosine kinase activity • phosphotyrosine residue binding Cellular component • cytoplasm • cytosol • extrinsic component of cytoplasmic side of plasma membrane • actin cytoskeleton • cytoskeleton Biological process • cellular response to retinoic acid • regulation of actin cytoskeleton reorganization • phosphorylation • positive regulation of phospholipase C activity • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of cytosolic calcium ion concentration • positive regulation of oxidoreductase activity • regulation of cell motility • protein phosphorylation • cell adhesion • cellular protein modification process • regulation of cell proliferation • positive regulation of neuron projection development • peptidyl-tyrosine autophosphorylation • peptidyl-tyrosine phosphorylation • innate immune system • signal transduction • regulation of autophagy • regulation of endocytosis • regulation of cell adhesion • cell differentiation • negative regulation of Rho protein signal transduction • exploration behavior Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	27	11352
Ensembl	ENSG00000143322	ENSMUSG00000026596
UniProt	P42684	Q4JIM5
RefSeq (mRNA)	NM_001136000 NM_001136001 NM_001168236 NM_001168237 NM_001168238 NM_001168239 NM_005158 NM_007314	NM_001136104 NM_009595
RefSeq (protein)	NP_001129472 NP_001129473 NP_001161708 NP_001161709 NP_001161710 NP_001161711 NP_005149 NP_009298	n/a
Location (UCSC)	Chr 1: 179.1 – 179.23 Mb	Chr 1: 156.56 – 156.65 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. The expression of ABL2 gene is higher in KRAS mutant non-small cell lung cancer.[7] The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length.[6]

Interactions

ABL2 has been shown to interact with three proteins: Abl gene,[8] catalase,[9] and SORBS2.[10] The protein Abl gene is also known as abelson murine leukemia viral oncogene homolog 1 and is a protein that is encoded by the human ABL1 gene.[11] Catalase is a common enzyme that catalyzes the decomposition of hydrogen peroxide to water and oxygen.[12] SORBS2 is also known as Sorbin and SH3 domain-containing protein 2 and is a protein encoded by the SORBS2 gene in humans.[6][10][13]

References

1. GRCh38: Ensembl release 89: ENSG00000143322 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026596 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kruh GD, King CR, Kraus MH, Popescu NC, Amsbaugh SC, McBride WO, Aaronson SA (Jan 1987). "A novel human gene closely related to the abl proto-oncogene". Science. 234 (4783): 1545–8. doi:10.1126/science.3787260. PMID 3787260.
6. "Entrez Gene: ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)".
7. Nagy, Ádám; Pongor, Lőrinc Sándor; Szabó, András; Santarpia, Mariacarmela; Győrffy, Balázs (2017-02-15). "KRAS driven expression signature has prognostic power superior to mutation status in non-small cell lung cancer". International Journal of Cancer. 140 (4): 930–937. doi:10.1002/ijc.30509. ISSN 1097-0215. PMC 5299512. PMID 27859136.
8. Cao C, Leng Y, Li C, Kufe D (April 2003). "Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response". J. Biol. Chem. 278 (15): 12961–7. doi:10.1074/jbc.M300058200. PMID 12569093.
9. Cao C, Leng Y, Kufe D (August 2003). "Catalase activity is regulated by c-Abl and Arg in the oxidative stress response". J. Biol. Chem. 278 (32): 29667–75. doi:10.1074/jbc.M301292200. PMID 12777400.
10. Wang B, Golemis EA, Kruh GD (July 1997). "ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks". J. Biol. Chem. 272 (28): 17542–50. doi:10.1074/jbc.272.28.17542. PMID 9211900.
11. Szczylik C, Skorski T, Nicolaides NC, Manzella L, Malaguarnera L, Venturelli D, Gewirtz AM, Calabretta B (August 1991). "Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligodeoxynucleotides". Science. 253 (5019): 562–5. doi:10.1126/science.1857987. PMID 1857987.
12. Chelikani P, Fita I, Loewen PC (January 2004). "Diversity of structures and properties among catalases". Cell. Mol. Life Sci. 61 (2): 192–208. doi:10.1007/s00018-003-3206-5. hdl:10261/111097. PMID 14745498.
13. Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.

Further reading

• Bradley WD, Koleske AJ (2009). "Regulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contexts". J Cell Sci. 122 (19): 3441–54. doi:10.1242/jcs.039859. PMC 2746129. PMID 19759284.
• Pendergast AM (2003). "The Abl family kinases: mechanisms of regulation and signaling". Adv. Cancer Res. Advances in Cancer Research. 85: 51–100. doi:10.1016/S0065-230X(02)85003-5. ISBN 0120066858. PMID 12374288.
• Muller AJ, Pendergast AM, Havlik MH, et al. (1992). "A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction". Mol. Cell. Biol. 12 (11): 5087–93. doi:10.1128/mcb.12.11.5087. PMC 360442. PMID 1383690.
• Kruh GD, Perego R, Miki T, Aaronson SA (1990). "The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases". Proc. Natl. Acad. Sci. U.S.A. 87 (15): 5802–6. doi:10.1073/pnas.87.15.5802. PMC 54416. PMID 2198571.
• Kruh GD, King CR, Kraus MH, et al. (1987). "A novel human gene closely related to the abl proto-oncogene". Science. 234 (4783): 1545–8. doi:10.1126/science.3787260. PMID 3787260.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Wang B, Kruh GD (1996). "Subcellular localization of the Arg protein tyrosine kinase". Oncogene. 13 (1): 193–7. PMID 8700546.
• Wang B, Mysliwiec T, Feller SM, et al. (1996). "Proline-rich sequences mediate the interaction of the Arg protein tyrosine kinase with Crk". Oncogene. 13 (7): 1379–85. PMID 8875975.
• Wang B, Golemis EA, Kruh GD (1997). "ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks". J. Biol. Chem. 272 (28): 17542–50. doi:10.1074/jbc.272.28.17542. PMID 9211900.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Koval AP, Blakesley VA, Roberts CT, et al. (1998). "Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor". Biochem. J. 330 (2): 923–32. doi:10.1042/bj3300923. PMC 1219226. PMID 9480911.
• Hashimoto Y, Katayama H, Kiyokawa E, et al. (1998). "Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor". J. Biol. Chem. 273 (27): 17186–91. doi:10.1074/jbc.273.27.17186. PMID 9642287.
• Danial NN, Losman JA, Lu T, et al. (1998). "Direct interaction of Jak1 and v-Abl is required for v-Abl-induced activation of STATs and proliferation". Mol. Cell. Biol. 18 (11): 6795–804. doi:10.1128/mcb.18.11.6795. PMC 109263. PMID 9774693.
• Cao C, Ren X, Kharbanda S, et al. (2001). "The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress". J. Biol. Chem. 276 (15): 11465–8. doi:10.1074/jbc.C100050200. PMID 11278261.
• Yu HH, Zisch AH, Dodelet VC, Pasquale EB (2001). "Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor". Oncogene. 20 (30): 3995–4006. doi:10.1038/sj.onc.1204524. PMID 11494128.
• Endo A, Nagashima K, Kurose H, et al. (2002). "Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII". J. Biol. Chem. 277 (26): 23747–54. doi:10.1074/jbc.M111794200. PMID 11956190.
• Abassi YA, Vuori K (2002). "Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling". EMBO J. 21 (17): 4571–82. doi:10.1093/emboj/cdf446. PMC 126186. PMID 12198159.
• Bianchi C, Muradore I, Corizzato M, et al. (2002). "The expression of the non-receptor tyrosine kinases Arg and c-abl is differently modulated in B lymphoid cells at different stages of differentiation". FEBS Lett. 527 (1–3): 216–222. doi:10.1016/S0014-5793(02)03233-7. PMID 12220663.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Salomon AR, Ficarro SB, Brill LM, et al. (2003). "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 443–8. doi:10.1073/pnas.2436191100. PMC 141014. PMID 12522270.

External links

• Genes,+abl at the US National Library of Medicine Medical Subject Headings (MeSH)
• Abelson+Leukemia+Virus at the US National Library of Medicine Medical Subject Headings (MeSH)
• ABL2 Info with links in the Cell Migration Gateway
• Human ABL2 genome location and ABL2 gene details page in the UCSC Genome Browser.