TEC (gene)

Tyrosine-protein kinase Tec is an enzyme that in humans is encoded by the TEC gene.[5][6]

TEC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LUL
Identifiers
Aliases	TEC, PSCTK4, tec protein tyrosine kinase
External IDs	OMIM: 600583 MGI: 98662 HomoloGene: 1302 GeneCards: TEC
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p12-p11 Start 48,135,783 bp[1] End 48,269,838 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 C3.2|5 38.44 cM Start 72,755,716 bp[2] End 72,868,483 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • non-membrane spanning protein tyrosine kinase activity • metal ion binding • kinase activity • GO:0001948 protein binding • protein tyrosine kinase activity • receptor binding • phospholipid binding • ATP binding • lipid binding Cellular component • cytoplasm • cytosol • membrane • extrinsic component of cytoplasmic side of plasma membrane • cytoskeleton • cell membrane Biological process • B cell receptor signaling pathway • cell differentiation • GO:0007243 intracellular signal transduction • adaptive immune response • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • immune system process • Fc-epsilon receptor signaling pathway • protein phosphorylation • regulation of cell proliferation • positive regulation of peptidyl-tyrosine phosphorylation • peptidyl-tyrosine autophosphorylation • integrin-mediated signaling pathway • peptidyl-tyrosine phosphorylation • regulation of platelet activation • innate immune system • tissue regeneration • cytokine-mediated signaling pathway • T cell receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7006	21682
Ensembl	ENSG00000135605	ENSMUSG00000029217
UniProt	P42680	P24604
RefSeq (mRNA)	NM_003215	NM_001113460 NM_001113461 NM_001113464 NM_013689
RefSeq (protein)	NP_003206	NP_001106931 NP_001106932 NP_001106935 NP_038717
Location (UCSC)	Chr 4: 48.14 – 48.27 Mb	Chr 5: 72.76 – 72.87 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein-coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.[6]

Interactions

TEC (gene) has been shown to interact with:

• ARHGEF12,[7]
• CD117,[8][9]
• DOK1,[8][10]
• GNA12,[7]
• Janus kinase 2,[11][12] and
• Suppressor of cytokine signaling 1.[13]

References

1. GRCh38: Ensembl release 89: ENSG00000135605 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029217 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sato K, Mano H, Ariyama T, Inazawa J, Yazaki Y, Hirai H (Oct 1994). "Molecular cloning and analysis of the human Tec protein-tyrosine kinase". Leukemia. 8 (10): 1663–72. PMID 7934162.
6. "Entrez Gene: TEC tec protein tyrosine kinase".
7. Suzuki N, Nakamura S, Mano H, Kozasa T (Jan 2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proceedings of the National Academy of Sciences of the United States of America. 100 (2): 733–8. doi:10.1073/pnas.0234057100. PMC 141065. PMID 12515866.
8. van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Löwenberg B, von Lindern M (Nov 2000). "Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells". Blood. 96 (10): 3406–13. doi:10.1182/blood.V96.10.3406. PMID 11071635.
9. Tang B, Mano H, Yi T, Ihle JN (Dec 1994). "Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding". Molecular and Cellular Biology. 14 (12): 8432–7. doi:10.1128/MCB.14.12.8432. PMC 359382. PMID 7526158.
10. Liang X, Wisniewski D, Strife A, Clarkson B, Resh MD (Apr 2002). "Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling". The Journal of Biological Chemistry. 277 (16): 13732–8. doi:10.1074/jbc.M200277200. PMID 11825908.
11. Takahashi-Tezuka M, Hibi M, Fujitani Y, Fukada T, Yamaguchi T, Hirano T (May 1997). "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK". Oncogene. 14 (19): 2273–82. doi:10.1038/sj.onc.1201071. PMID 9178903.
12. Yamashita Y, Watanabe S, Miyazato A, Ohya Ki, Ikeda U, Shimada K, Komatsu N, Hatake K, Miura Y, Ozawa K, Mano H (Mar 1998). "Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription". Blood. 91 (5): 1496–507. doi:10.1182/blood.V91.5.1496. PMID 9473212.
13. Ohya Ki, Kajigaya S, Yamashita Y, Miyazato A, Hatake K, Miura Y, Ikeda U, Shimada K, Ozawa K, Mano H (Oct 1997). "SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase". The Journal of Biological Chemistry. 272 (43): 27178–82. doi:10.1074/jbc.272.43.27178. PMID 9341160.

Further reading

• Mano H (2000). "Tec family of protein-tyrosine kinases: an overview of their structure and function". Cytokine & Growth Factor Reviews. 10 (3–4): 267–80. doi:10.1016/S1359-6101(99)00019-2. PMID 10647781.
• Yang WC, Collette Y, Nunès JA, Olive D (Apr 2000). "Tec kinases: a family with multiple roles in immunity". Immunity. 12 (4): 373–82. doi:10.1016/S1074-7613(00)80189-2. PMID 10795735.
• Mano H, Ishikawa F, Nishida J, Hirai H, Takaku F (Dec 1990). "A novel protein-tyrosine kinase, tec, is preferentially expressed in liver". Oncogene. 5 (12): 1781–6. PMID 2284097.
• Tang B, Mano H, Yi T, Ihle JN (Dec 1994). "Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding". Molecular and Cellular Biology. 14 (12): 8432–7. doi:10.1128/MCB.14.12.8432. PMC 359382. PMID 7526158.
• Machide M, Mano H, Todokoro K (Aug 1995). "Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain". Oncogene. 11 (4): 619–25. PMID 7651724.
• Mano H, Yamashita Y, Miyazato A, Miura Y, Ozawa K (Apr 1996). "Tec protein-tyrosine kinase is an effector molecule of Lyn protein-tyrosine kinase". FASEB Journal. 10 (5): 637–42. doi:10.1096/fasebj.10.5.8621063. PMID 8621063. S2CID 27064487.
• Rawlings DJ, Scharenberg AM, Park H, Wahl MI, Lin S, Kato RM, Fluckiger AC, Witte ON, Kinet JP (Feb 1996). "Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases". Science. 271 (5250): 822–5. doi:10.1126/science.271.5250.822. PMID 8629002. S2CID 42666246.
• Park H, Wahl MI, Afar DE, Turck CW, Rawlings DJ, Tam C, Scharenberg AM, Kinet JP, Witte ON (May 1996). "Regulation of Btk function by a major autophosphorylation site within the SH3 domain". Immunity. 4 (5): 515–25. doi:10.1016/S1074-7613(00)80417-3. PMID 8630736.
• Ohta Y, Haire RN, Amemiya CT, Litman RT, Träger T, Riess O, Litman GW (Feb 1996). "Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene". Oncogene. 12 (4): 937–42. PMID 8632917.
• Cory GO, MacCarthy-Morrogh L, Banin S, Gout I, Brickell PM, Levinsky RJ, Kinnon C, Lovering RC (Nov 1996). "Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways". Journal of Immunology. 157 (9): 3791–5. PMID 8892607.
• Takahashi-Tezuka M, Hibi M, Fujitani Y, Fukada T, Yamaguchi T, Hirano T (May 1997). "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK". Oncogene. 14 (19): 2273–82. doi:10.1038/sj.onc.1201071. PMID 9178903.
• Laffargue M, Monnereau L, Tuech J, Ragab A, Ragab-Thomas J, Payrastre B, Raynal P, Chap H (Sep 1997). "Integrin-dependent tyrosine phoshorylation and cytoskeletal translocation of Tec in thrombin-activated platelets". Biochemical and Biophysical Research Communications. 238 (1): 247–51. doi:10.1006/bbrc.1997.7269. PMID 9299487.
• Kitanaka A, Mano H, Conley ME, Campana D (Feb 1998). "Expression and activation of the nonreceptor tyrosine kinase Tec in human B cells". Blood. 91 (3): 940–8. doi:10.1182/blood.V91.3.940. PMID 9446655.
• Yang WC, Ghiotto M, Barbarat B, Olive D (Jan 1999). "The role of Tec protein-tyrosine kinase in T cell signaling". The Journal of Biological Chemistry. 274 (2): 607–17. doi:10.1074/jbc.274.2.607. PMID 9872994.
• Yang WC, Olive D (Jun 1999). "Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in the CD28 pathway". European Journal of Immunology. 29 (6): 1842–9. doi:10.1002/(SICI)1521-4141(199906)29:06<1842::AID-IMMU1842>3.0.CO;2-D. PMID 10382746.
• Ohya K, Kajigaya S, Kitanaka A, Yoshida K, Miyazato A, Yamashita Y, Yamanaka T, Ikeda U, Shimada K, Ozawa K, Mano H (Oct 1999). "Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase". Proceedings of the National Academy of Sciences of the United States of America. 96 (21): 11976–81. doi:10.1073/pnas.96.21.11976. PMC 18397. PMID 10518561.

External links

• Overview of all the structural information available in the PDB for UniProt: P42680 (Human Tyrosine-protein kinase Tec) at the PDBe-KB.
• Overview of all the structural information available in the PDB for UniProt: P24604 (Mouse Tyrosine-protein kinase Tec) at the PDBe-KB.