ACOT12

Acyl-coenzyme A thioesterase 12 or StAR-related lipid transfer protein 15 (STARD15) is an enzyme that in humans is encoded by the ACOT12 gene.[5][6][7] The protein contains a StAR-related lipid transfer domain.

ACOT12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3B7K, 4MOB, 4MOC
Identifiers
Aliases	ACOT12, CACH-1, Cach, STARD15, THEAL, acyl-CoA thioesterase 12
External IDs	OMIM: 614315 MGI: 1921406 HomoloGene: 12540 GeneCards: ACOT12
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q14.1 Start 81,329,996 bp[1] End 81,394,179 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 C3 Start 91,741,512 bp[2] End 91,786,148 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0004091 carboxylic ester hydrolase activity • ATP binding • hydrolase activity • lipid binding • acetyl-CoA hydrolase activity • acyl-CoA hydrolase activity • fatty-acyl-CoA binding • palmitoyl-CoA hydrolase activity • long-chain fatty acyl-CoA binding • thiolester hydrolase activity Cellular component • cytoplasm • cytosol Biological process • pyruvate metabolic process • lipid metabolism • acyl-CoA metabolic process • acetyl-CoA metabolic process • fatty acid metabolic process • palmitic acid biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	134526	74156
Ensembl	ENSG00000172497	ENSMUSG00000021620
UniProt	Q8WYK0	Q9DBK0
RefSeq (mRNA)	NM_130767	NM_028790
RefSeq (protein)	NP_570123	NP_083066
Location (UCSC)	Chr 5: 81.33 – 81.39 Mb	Chr 13: 91.74 – 91.79 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000172497 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021620 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (Aug 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". J Lipid Res. 46 (9): 2029–32. doi:10.1194/jlr.E500003-JLR200. PMID 16103133.
6. Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (Aug 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB J. 20 (11): 1855–64. doi:10.1096/fj.06-6042com. PMID 16940157. S2CID 501610.
7. "Entrez Gene: ACOT12 acyl-CoA thioesterase 12".

External links

• Human ACOT12 genome location and ACOT12 gene details page in the UCSC Genome Browser.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Acetyl-coenzyme A thioesterase

Further reading

• Suematsu N, Isohashi F (2007). "Molecular cloning and functional expression of human cytosolic acetyl-CoA hydrolase". Acta Biochim. Pol. 53 (3): 553–61. doi:10.18388/abp.2006_3327. PMID 16951743.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Suematsu N, Okamoto K, Isohashi F (2004). "Simple and unique purification by size-exclusion chromatography for an oligomeric enzyme, rat liver cytosolic acetyl-coenzyme A hydrolase". J. Chromatogr. B. 790 (1–2): 239–44. doi:10.1016/s1570-0232(03)00167-3. PMID 12767336.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suematsu N, Okamoto K, Shibata K, et al. (2001). "Molecular cloning and functional expression of rat liver cytosolic acetyl-CoA hydrolase". Eur. J. Biochem. 268 (9): 2700–9. doi:10.1046/j.1432-1327.2001.02162.x. PMID 11322891.