ARR3

Arrestin-C also known as retinal cone arrestin-3 is a protein that in humans is encoded by the ARR3 gene.[5][6]

ARR3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XEH, 2A34
Identifiers
Aliases	ARR3, ARRX, cArr, arrestin 3 retinal (X-arrestin), arrestin 3, MYP26
External IDs	OMIM: 301770 MGI: 2159617 HomoloGene: 3182 GeneCards: ARR3
Gene location (Human) Chr. X chromosome (human)[1] Band Xq13.1 Start 70,268,305 bp[1] End 70,281,840 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X C3 Start 100,605,497 bp[2] End 100,618,493 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • phosphoprotein binding • opsin binding • GO:0001948 protein binding • G-protein coupled receptor binding Cellular component • photoreceptor inner segment • cytoplasm • photoreceptor outer segment • synapse Biological process • regulation of protein phosphorylation • endocytosis • signal transduction • visual perception • response to stimulus • G-protein coupled receptor internalization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	407	170735
Ensembl	ENSG00000120500	ENSMUSG00000060890
UniProt	P36575	Q9EQP6
RefSeq (mRNA)	NM_004312	NM_133205
RefSeq (protein)	NP_004303	NP_573468
Location (UCSC)	Chr X: 70.27 – 70.28 Mb	Chr X: 100.61 – 100.62 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• arrestin

References

1. GRCh38: Ensembl release 89: ENSG00000120500 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060890 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Murakami A, Yajima T, Sakuma H, McLaren MJ, Inana G (Dec 1993). "X-arrestin: a new retinal arrestin mapping to the X chromosome". FEBS Lett. 334 (2): 203–9. doi:10.1016/0014-5793(93)81712-9. PMID 8224247.
6. "Entrez Gene: ARR3 arrestin 3, retinal (X-arrestin)".

Further reading

• Craft CM, Whitmore DH, Wiechmann AF (1994). "Cone arrestin identified by targeting expression of a functional family". J. Biol. Chem. 269 (6): 4613–9. PMID 8308033.
• Sakuma H, Inana G, Murakami A, et al. (1996). "Immunolocalization of X-arrestin in human cone photoreceptors". FEBS Lett. 382 (1–2): 105–10. doi:10.1016/0014-5793(96)00163-9. PMID 8612728.
• ter Haar E, Musacchio A, Harrison SC, Kirchhausen T (1998). "Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker". Cell. 95 (4): 563–73. doi:10.1016/S0092-8674(00)81623-2. PMC 4428171. PMID 9827808.
• Orsini MJ, Benovic JL (1999). "Characterization of dominant negative arrestins that inhibit beta2-adrenergic receptor internalization by distinct mechanisms". J. Biol. Chem. 273 (51): 34616–22. doi:10.1074/jbc.273.51.34616. PMID 9852134.
• Sakuma H, Murakami A, Fujimaki T, Inana G (1999). "Isolation and characterization of the human X-arrestin gene". Gene. 224 (1–2): 87–95. doi:10.1016/S0378-1119(98)00510-1. PMID 9931451.
• John SK, Smith JE, Aguirre GD, Milam AH (2000). "Loss of cone molecular markers in rhodopsin-mutant human retinas with retinitis pigmentosa". Mol. Vis. 6: 204–15. PMID 11063754.
• Chen Z, Dupré DJ, Le Gouill C, et al. (2002). "Agonist-induced internalization of the platelet-activating factor receptor is dependent on arrestins but independent of G-protein activation. Role of the C terminus and the (D/N)PXXY motif". J. Biol. Chem. 277 (9): 7356–62. doi:10.1074/jbc.M110058200. PMID 11729201.
• Kim YM, Barak LS, Caron MG, Benovic JL (2002). "Regulation of arrestin-3 phosphorylation by casein kinase II". J. Biol. Chem. 277 (19): 16837–46. doi:10.1074/jbc.M201379200. PMID 11877451.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhu X, Li A, Brown B, et al. (2002). "Mouse cone arrestin expression pattern: light induced translocation in cone photoreceptors". Mol. Vis. 8: 462–71. PMID 12486395.
• Zhang H, Cuenca N, Ivanova T, et al. (2003). "Identification and light-dependent translocation of a cone-specific antigen, cone arrestin, recognized by monoclonal antibody 7G6". Invest. Ophthalmol. Vis. Sci. 44 (7): 2858–67. doi:10.1167/iovs.03-0072. PMID 12824223.
• Krishnamurthy H, Galet C, Ascoli M (2004). "The association of arrestin-3 with the follitropin receptor depends on receptor activation and phosphorylation". Mol. Cell. Endocrinol. 204 (1–2): 127–40. doi:10.1016/S0303-7207(03)00088-1. PMID 12850288.
• Zhu X, Brown B, Li A, et al. (2003). "GRK1-dependent phosphorylation of S and M opsins and their binding to cone arrestin during cone phototransduction in the mouse retina". J. Neurosci. 23 (14): 6152–60. doi:10.1523/JNEUROSCI.23-14-06152.2003. PMC 6740345. PMID 12853434.
• Ermakova NA, Alekberova ZS, Prokaeva TB (2003). Autoimmunity to S-antigen and retinal vasculitis in patients with Behçet's disease. Adv. Exp. Med. Biol. Advances in Experimental Medicine and Biology. 528. pp. 279–81. doi:10.1007/0-306-48382-3_56. ISBN 978-0-306-47757-7. PMID 12918707.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

• Human ARR3 genome location and ARR3 gene details page in the UCSC Genome Browser.